Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives
Background: Research involving snake venom has gradually surpassed the simple discovery of new molecules using purification and structural characterization processes, and extended to the identification of their molecular targets and the evaluation of their therapeutic potential. Nevertheless, this o...
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| Бусад зохиолчид: | , , , , , , , , , , , , |
| Формат: | article |
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2018
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| Нөхцлүүд: | |
| Онлайн хандалт: | http://repositorio.ikiam.edu.ec:8080/jspui/handle/RD_IKIAM/240 http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/240 https://doi.org/10.2174/1389201019666180620111025 |
| Шошгууд: |
Шошго нэмэх
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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Шошго нэмэх | _version_ | 1858435698558763008 |
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| author | Simoes Silva, Rodrigo |
| author2 | Alfonso, Jorge Gomez, Ana F. Holanda, Rudson J. Sobrinho, Juliana C. Zaqueo, Kayena D. Moreira Dill, Leandro S. Kayano, Anderson M. Grabner, Fernando P. da Silva, Saulo L. de Almeida, José R. Stabeli, Rodrigo G. Zuliani, Juliana P. Soares, Andreimar M. |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Simoes Silva, Rodrigo Alfonso, Jorge Gomez, Ana F. Holanda, Rudson J. Sobrinho, Juliana C. Zaqueo, Kayena D. Moreira Dill, Leandro S. Kayano, Anderson M. Grabner, Fernando P. da Silva, Saulo L. de Almeida, José R. Stabeli, Rodrigo G. Zuliani, Juliana P. Soares, Andreimar M. |
| author_role | author |
| collection | Repositorio Universidad Regional Amazónica |
| dc.creator.none.fl_str_mv | Simoes Silva, Rodrigo Alfonso, Jorge Gomez, Ana F. Holanda, Rudson J. Sobrinho, Juliana C. Zaqueo, Kayena D. Moreira Dill, Leandro S. Kayano, Anderson M. Grabner, Fernando P. da Silva, Saulo L. de Almeida, José R. Stabeli, Rodrigo G. Zuliani, Juliana P. Soares, Andreimar M. |
| dc.date.none.fl_str_mv | 2018 2019-06-12T15:29:46Z 2019-06-12T15:29:46Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | Simoes-Silva, R., Alfonso, J., Gomez, A., Holanda, R. J., Sobrinho, J. C., Zaqueo, K. D., … Soares, A. M. (2018). Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives. Current Pharmaceutical Biotechnology, 19(4), 308–335. doi:10.2174/1389201019666180620111025 http://repositorio.ikiam.edu.ec:8080/jspui/handle/RD_IKIAM/240 http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/240 https://doi.org/10.2174/1389201019666180620111025 |
| dc.language.none.fl_str_mv | en |
| dc.publisher.none.fl_str_mv | Bentham Science |
| dc.relation.none.fl_str_mv | PRODUCCIÓN CIENTÍFICA-ARTÍCULOS;A-IKIAM-000177 |
| dc.rights.none.fl_str_mv | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América http://creativecommons.org/licenses/by-nc-nd/3.0/us/ info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositorio Universidad Regional Amazónica instname:Universidad Regional Amazónica instacron:IKIAM |
| dc.subject.none.fl_str_mv | Snake venoms Venomics Protein purification Toxins Biotechnological applications New therapeutics. |
| dc.title.none.fl_str_mv | Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Background: Research involving snake venom has gradually surpassed the simple discovery of new molecules using purification and structural characterization processes, and extended to the identification of their molecular targets and the evaluation of their therapeutic potential. Nevertheless, this only became possible due to constant progress in experimental biology and protein purification approaches. Objective: This review aims to discuss the main components of snake venoms that have been investigated for biotechnological purposes, and to discover how these promising biomolecules were obtained with the satisfactory degree of purity that have enabled such studies. Advances in purification technologies of various snake venom molecules have allowed for important discoveries of proteins and peptides with different biomedical and biotechnological applications. Result and Conclusion: It is believed that significant experimental and computational advances will arise in similar proportions in the coming years that will allow researchers to map the molecular regions responsible for their pharmacological actions, their respective mechanisms of action and their cell targets. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | IKIAM_ba5bcd2271e5cc198ee5b5f5040cc014 |
| identifier_str_mv | Simoes-Silva, R., Alfonso, J., Gomez, A., Holanda, R. J., Sobrinho, J. C., Zaqueo, K. D., … Soares, A. M. (2018). Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives. Current Pharmaceutical Biotechnology, 19(4), 308–335. doi:10.2174/1389201019666180620111025 |
| instacron_str | IKIAM |
| institution | IKIAM |
| instname_str | Universidad Regional Amazónica |
| language_invalid_str_mv | en |
| network_acronym_str | IKIAM |
| network_name_str | Repositorio Universidad Regional Amazónica |
| oai_identifier_str | oai:repositorio.ikiam.edu.ec:RD_IKIAM/240 |
| publishDate | 2018 |
| publisher.none.fl_str_mv | Bentham Science |
| reponame_str | Repositorio Universidad Regional Amazónica |
| repository.mail.fl_str_mv | . |
| repository.name.fl_str_mv | Repositorio Universidad Regional Amazónica - Universidad Regional Amazónica |
| repository_id_str | 0 |
| rights_invalid_str_mv | Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de América http://creativecommons.org/licenses/by-nc-nd/3.0/us/ |
| spelling | Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current PerspectivesSimoes Silva, RodrigoAlfonso, JorgeGomez, Ana F.Holanda, Rudson J.Sobrinho, Juliana C.Zaqueo, Kayena D.Moreira Dill, Leandro S.Kayano, Anderson M.Grabner, Fernando P.da Silva, Saulo L.de Almeida, José R.Stabeli, Rodrigo G.Zuliani, Juliana P.Soares, Andreimar M.Snake venomsVenomicsProtein purificationToxinsBiotechnological applicationsNew therapeutics.Background: Research involving snake venom has gradually surpassed the simple discovery of new molecules using purification and structural characterization processes, and extended to the identification of their molecular targets and the evaluation of their therapeutic potential. Nevertheless, this only became possible due to constant progress in experimental biology and protein purification approaches. Objective: This review aims to discuss the main components of snake venoms that have been investigated for biotechnological purposes, and to discover how these promising biomolecules were obtained with the satisfactory degree of purity that have enabled such studies. Advances in purification technologies of various snake venom molecules have allowed for important discoveries of proteins and peptides with different biomedical and biotechnological applications. Result and Conclusion: It is believed that significant experimental and computational advances will arise in similar proportions in the coming years that will allow researchers to map the molecular regions responsible for their pharmacological actions, their respective mechanisms of action and their cell targets.Bentham Science2019-06-12T15:29:46Z2019-06-12T15:29:46Z2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfSimoes-Silva, R., Alfonso, J., Gomez, A., Holanda, R. J., Sobrinho, J. C., Zaqueo, K. D., … Soares, A. M. (2018). Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives. Current Pharmaceutical Biotechnology, 19(4), 308–335. doi:10.2174/1389201019666180620111025http://repositorio.ikiam.edu.ec:8080/jspui/handle/RD_IKIAM/240http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/240https://doi.org/10.2174/1389201019666180620111025enPRODUCCIÓN CIENTÍFICA-ARTÍCULOS;A-IKIAM-000177Atribución-NoComercial-SinDerivadas 3.0 Estados Unidos de Américahttp://creativecommons.org/licenses/by-nc-nd/3.0/us/info:eu-repo/semantics/openAccessreponame:Repositorio Universidad Regional Amazónicainstname:Universidad Regional Amazónicainstacron:IKIAM2022-06-04T08:03:36Zoai:repositorio.ikiam.edu.ec:RD_IKIAM/240Institucionalhttps://repositorio.ikiam.edu.ec/Universidad públicahttps://www.ikiam.edu.ec/https://repositorio.ikiam.edu.ec/oaiEcuador...opendoar:02022-06-04T08:03:36falseInstitucionalhttps://repositorio.ikiam.edu.ec/Universidad públicahttps://www.ikiam.edu.ec/https://repositorio.ikiam.edu.ec/oai.Ecuador...opendoar:02022-06-04T08:03:36Repositorio Universidad Regional Amazónica - Universidad Regional Amazónicafalse |
| spellingShingle | Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives Simoes Silva, Rodrigo Snake venoms Venomics Protein purification Toxins Biotechnological applications New therapeutics. |
| status_str | publishedVersion |
| title | Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives |
| title_full | Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives |
| title_fullStr | Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives |
| title_full_unstemmed | Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives |
| title_short | Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives |
| title_sort | Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives |
| topic | Snake venoms Venomics Protein purification Toxins Biotechnological applications New therapeutics. |
| url | http://repositorio.ikiam.edu.ec:8080/jspui/handle/RD_IKIAM/240 http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/240 https://doi.org/10.2174/1389201019666180620111025 |