Xantoastrocitoma pleomórfico

The pleomorphic xantoastrocytoma, due to its extreme rarity, carries high complexity in the histo-pathological diagnosis. The clinical case is presented in a male subject, 40 years old, with a history of sei-zures with late presentation, secondary to atypical meningioma grade II located in the left occipital region, resected twice in the course of 6 years. He received full-dose radiation therapy after the second resection. The initial histopathological diagnosis was atypical meningioma grade II. The patient comes to HCAM due to intense holocranial headache and right brachiocrural hemiparesis; In the gadolinium nuclear magnetic resonance studies the growth of a left occipital lesion with perilesional edema that warranted total resec-tion of the lesion through previouscraniectomy was observed. As a macroscopic finding, a violaceous mass is described which infiltrates dura mater lacking a plane of cleavage; The histopathological study details a hypercellular glial neoplasia with diffuse infiltration with intense immunohistochemical reaction for PGAF (glial acidic glial protein), S100 and CD56 in tumor cells, CD34 positive. It was KI67 positive in 3% and P53 weakly positive, compatible with pleomorphicxantoastrocytoma WHO II.

• Huvudupphovsman: León, Carlos Alberto (author)
• Övriga upphovsmän: Acosta, José Leonardo (author), Diez, Christian Xavier (author)
• Materialtyp: article
• Språk: spa
• Publicerad: 2017
• Ämnen: xantoastrocitoma pleomórfico; meningioma atípico recidivante; xantoma fibroso; astrocitoma grado II; xanthoastrocytoma pleomorphic; atypical recurrent meningioma; fibrous xanthoma; astrocy-toma grade II
• Länkar: https://revistadigital.uce.edu.ec/index.php/CIENCIAS_MEDICAS/article/view/1582