Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study.
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| Format: | article |
| Idioma: | eng |
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2024
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| Accés en línia: | https://www.dspace.uce.edu.ec/handle/25000/35088 |
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Afegir etiqueta | _version_ | 1824209361336008704 |
|---|---|
| author | Gimenez Miniello, Thaís |
| author2 | Brasileiro, Gabriela Garrido, Eduardo Fagundes Pedroni, Ana Clara Mota, Maria Emília Moreira, Maria Stella Martins Marques, Márcia |
| author2_role | author author author author author author |
| author_facet | Gimenez Miniello, Thaís Brasileiro, Gabriela Garrido, Eduardo Fagundes Pedroni, Ana Clara Mota, Maria Emília Moreira, Maria Stella Martins Marques, Márcia |
| author_role | author |
| collection | Repositorio de la Universidad Central del Ecuador |
| dc.creator.none.fl_str_mv | Gimenez Miniello, Thaís Brasileiro, Gabriela Garrido, Eduardo Fagundes Pedroni, Ana Clara Mota, Maria Emília Moreira, Maria Stella Martins Marques, Márcia |
| dc.date.none.fl_str_mv | 2024-10-22T15:59:42Z 2024-10-22T15:59:42Z 2024-10-02 |
| dc.format.none.fl_str_mv | 10 páginas application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | Miniello, T.G., Brasileiro, G., Garrido, E. et al. Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. Laser Dent Sci 8, 46 (2024). https://doi.org/10.1007/s41547-024-00262-0 2367-2587 https://www.dspace.uce.edu.ec/handle/25000/35088 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Springer International Publishing AG Switzerland |
| dc.relation.none.fl_str_mv | 10 Número 46 1 Volmen 8 Lasers in Dental Science |
| dc.rights.none.fl_str_mv | Atribución 4.0 Internacional (CC BY 4.0) info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | https://link.springer.com/article/10.1007/s41547-024-00262-0#article-info https://link.springer.com/journal/41547 reponame:Repositorio de la Universidad Central del Ecuador instname:Universidad Central del Ecuador instacron:UCE |
| dc.subject.none.fl_str_mv | Medication-related osteonecrosis of the jaw Photobiomodulation Antimicrobial photodynamic therapy Platelet-rich fibrin Bone regeneration |
| dc.title.none.fl_str_mv | Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. |
| dc.type.none.fl_str_mv | Artículo de revista http://purl.org/coar/resource_type/c_2df8fbb1 http://purl.org/coar/version/c_970fb48d4fbd8a85 Text info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | ilustraciones. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UCE_26a61c9ef5bd07c929bb3d136f36d951 |
| identifier_str_mv | Miniello, T.G., Brasileiro, G., Garrido, E. et al. Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. Laser Dent Sci 8, 46 (2024). https://doi.org/10.1007/s41547-024-00262-0 2367-2587 |
| instacron_str | UCE |
| institution | UCE |
| instname_str | Universidad Central del Ecuador |
| language | eng |
| network_acronym_str | UCE |
| network_name_str | Repositorio de la Universidad Central del Ecuador |
| oai_identifier_str | oai:dspace.uce.edu.ec:25000/35088 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Springer International Publishing AG Switzerland |
| reponame_str | Repositorio de la Universidad Central del Ecuador |
| repository.mail.fl_str_mv | . |
| repository.name.fl_str_mv | Repositorio de la Universidad Central del Ecuador - Universidad Central del Ecuador |
| repository_id_str | 2487 |
| rights_invalid_str_mv | Atribución 4.0 Internacional (CC BY 4.0) |
| spelling | Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study.Gimenez Miniello, ThaísBrasileiro, GabrielaGarrido, EduardoFagundes Pedroni, Ana ClaraMota, Maria EmíliaMoreira, Maria StellaMartins Marques, MárciaMedication-related osteonecrosis of the jawPhotobiomodulationAntimicrobial photodynamic therapyPlatelet-rich fibrinBone regenerationilustraciones.Purpose This study aimed to compare the bone response of medication-related osteonecrosis of the jaw (MRONJ) treated with bone debridement associated with photobiomodulation (PBM), antimicrobial photodynamic therapy (aPDT) or plateletrich fibrin (PRF). Methods MRONJ was induced in 30 Wistar rats using zoledronate (0.06 mg/kg) followed by tooth extraction 21 days later. The experimental groups were no treatment (negative control), isolated debridement (positive control), or associated with aPDT, PBM, or PRF. Seven and 28 days after treatment morphometric analysis in microcomputed tomography images was performed. Data were statistically analyzed by two-way ANOVA (p ≤ 0.05). Results In the negative control, the MRONJ progressed, showing a significant decrease in bone volume (BV; p = 0.04). The PBM and PRF had the highest BV at 28 days (p = 0.02). The trabeculae number at 7 days was significantly higher in PRF (p = 0.03) compared to all other groups. At 7 days, the PRF had thicker trabeculae (p = 0.04). At 28 days, the positive control and PRF showed thicker trabeculae than the negative control (p = 0.02). Conclusion These results indicate the most positive responses of the bone of MRONJ-induced lesions after PRF and PBM treatments, accelerating the process of bone neoformation and regeneration in MRONJ.Springer International Publishing AGSwitzerland2024-10-22T15:59:42Z2024-10-22T15:59:42Z2024-10-02Artículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 páginasapplication/pdfapplication/pdfMiniello, T.G., Brasileiro, G., Garrido, E. et al. Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. Laser Dent Sci 8, 46 (2024). https://doi.org/10.1007/s41547-024-00262-02367-2587https://www.dspace.uce.edu.ec/handle/25000/35088https://link.springer.com/article/10.1007/s41547-024-00262-0#article-infohttps://link.springer.com/journal/41547reponame:Repositorio de la Universidad Central del Ecuadorinstname:Universidad Central del Ecuadorinstacron:UCEeng10Número 461Volmen 8Lasers in Dental ScienceAl consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.Atribución 4.0 Internacional (CC BY 4.0)info:eu-repo/semantics/openAccess2024-12-12T08:21:19Zoai:dspace.uce.edu.ec:25000/35088Institucionalhttp://www.dspace.uce.edu.ec/Universidad públicahttps://www.uce.edu.ec/http://www.dspace.uce.edu.ec/oai.Ecuador...opendoar:24872024-12-12T08:21:19Repositorio de la Universidad Central del Ecuador - Universidad Central del Ecuadorfalse |
| spellingShingle | Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. Gimenez Miniello, Thaís Medication-related osteonecrosis of the jaw Photobiomodulation Antimicrobial photodynamic therapy Platelet-rich fibrin Bone regeneration |
| status_str | publishedVersion |
| title | Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. |
| title_full | Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. |
| title_fullStr | Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. |
| title_full_unstemmed | Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. |
| title_short | Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. |
| title_sort | Bone regeneration after adjuvant therapies for medication-related osteonecrosis of the jaws (MRONJ): a pre-clinical study. |
| topic | Medication-related osteonecrosis of the jaw Photobiomodulation Antimicrobial photodynamic therapy Platelet-rich fibrin Bone regeneration |
| url | https://www.dspace.uce.edu.ec/handle/25000/35088 |