Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021
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| Format: | article |
| Jezik: | eng |
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2023
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| Online pristup: | https://www.dspace.uce.edu.ec/handle/25000/33043 |
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Dodaj oznaku | _version_ | 1824209350687719424 |
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| author | Saavedra, Julio C. |
| author2 | Fonseca, Deisy Abrahamyan, Arpine Thekkur, Pruthu Timire, Collins Reyes, Jorge Zachariah, Rony Agudelo, Lorena G. |
| author2_role | author author author author author author author |
| author_facet | Saavedra, Julio C. Fonseca, Deisy Abrahamyan, Arpine Thekkur, Pruthu Timire, Collins Reyes, Jorge Zachariah, Rony Agudelo, Lorena G. |
| author_role | author |
| collection | Repositorio de la Universidad Central del Ecuador |
| dc.coverage.none.fl_str_mv | Colombia |
| dc.creator.none.fl_str_mv | Saavedra, Julio C. Fonseca, Deisy Abrahamyan, Arpine Thekkur, Pruthu Timire, Collins Reyes, Jorge Zachariah, Rony Agudelo, Lorena G. |
| dc.date.none.fl_str_mv | 2023 2024-02-29T18:45:12Z 2024-02-29T18:45:12Z |
| dc.format.none.fl_str_mv | 8 páginas application/pdf application/pdf |
| dc.identifier.none.fl_str_mv | Saavedra JC, Fonseca D, Abrahamyan A, Thekkur P, Timire C, Reyes J, et al. Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021. Rev Panam Salud Publica. 2023;47:e18. https://doi.org/10.26633/RPSP.2023.18 1680-5348 https://www.dspace.uce.edu.ec/handle/25000/33043 1020-4989 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Pan American Health Organization United States |
| dc.relation.none.fl_str_mv | 8 1 Volmen 47, Numero 18 Pan American Journal of Public Health |
| dc.rights.none.fl_str_mv | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | https://doi.org/10.26633/RPSP.2023.18 reponame:Repositorio de la Universidad Central del Ecuador instname:Universidad Central del Ecuador instacron:UCE |
| dc.subject.none.fl_str_mv | Sepsis blood culture anti-bacterial agents drug resistance microbial |
| dc.title.none.fl_str_mv | Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021 |
| dc.type.none.fl_str_mv | Artículo de revista http://purl.org/coar/resource_type/c_2df8fbb1 http://purl.org/coar/version/c_970fb48d4fbd8a85 Text info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| description | tablas |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UCE_3b4f9157c2022690c33c5ed1b08d8af5 |
| identifier_str_mv | Saavedra JC, Fonseca D, Abrahamyan A, Thekkur P, Timire C, Reyes J, et al. Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021. Rev Panam Salud Publica. 2023;47:e18. https://doi.org/10.26633/RPSP.2023.18 1680-5348 1020-4989 |
| instacron_str | UCE |
| institution | UCE |
| instname_str | Universidad Central del Ecuador |
| language | eng |
| network_acronym_str | UCE |
| network_name_str | Repositorio de la Universidad Central del Ecuador |
| oai_identifier_str | oai:dspace.uce.edu.ec:25000/33043 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | Pan American Health Organization United States |
| reponame_str | Repositorio de la Universidad Central del Ecuador |
| repository.mail.fl_str_mv | . |
| repository.name.fl_str_mv | Repositorio de la Universidad Central del Ecuador - Universidad Central del Ecuador |
| repository_id_str | 2487 |
| rights_invalid_str_mv | Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0) |
| spelling | Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021Saavedra, Julio C.Fonseca, DeisyAbrahamyan, ArpineThekkur, PruthuTimire, CollinsReyes, JorgeZachariah, RonyAgudelo, Lorena G.Sepsisblood cultureanti-bacterial agentsdrug resistancemicrobialtablasObjectives. To assess antibiotic susceptibility of World Health Organization (WHO) priority bacteria (Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Salmonella spp., Staphylococcus aureus, and Streptococcus pneumoniae) in blood cultures at the Orinoquía regional hospital in Colombia. Methods. This was cross-sectional study using routine laboratory data for the period 2019–2021. Data on blood samples from patients suspected of a bloodstream infection were examined. We determined: the total number of blood cultures done and the proportion with culture yield; the characteristics of patients with priority bacteria; and the type of bacteria isolated and antibiotic resistance patterns. Results. Of 25 469 blood cultures done, 1628 (6%) yielded bacteria; 774 (48%) of these bacteria were WHO priority pathogens. Most of the priority bacteria isolated (558; 72%) were gram-negative and 216 (28%) were gram-positive organisms. Most patients with priority bacteria (666; 86%) were hospitalized in wards other than the intensive care unit, 427 (55%) were male, and 321 (42%) were ≥ 60 years of age. Of the 216 gram-positive bacteria isolated, 205 (95%) were Staphylococcus aureus. Of the 558 gram-negative priority bacteria isolated, the three most common were Escherichia coli (34%), Klebsiella pneumoniae (28%), and Acinetobacter baumannii (20%). The highest resistance of Staphylococcus aureus was to oxacillin (41%). For gram-negative bacteria, resistance to antibiotics ranged from 4% (amikacin) to 72% (ampicillin). Conclusions. Bacterial yield from blood cultures was low and could be improved. WHO priority bacteria were found in all hospital wards. This calls for rigorous infection prevention and control standards and continued surveillance of antibiotic resistance.bjetivos. Evaluar la sensibilidad a los antibióticos de las bacterias incluidas en la lista prioritaria de la Organización Mundial de la Salud (OMS) (Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Salmonella spp., Staphylococcus aureus y Streptococcus pneumoniae) en hemocultivos en el Hospital Regional de la Orinoquía en Colombia. Métodos. Se trata de un estudio transversal que empleó datos rutinarios de laboratorio del período comprendido entre los años 2019 y 2021. Se examinaron datos de muestras de sangre de pacientes con presunción clínica de infección del torrente sanguíneo. Se determinó el número total de hemocultivos realizados y la proporción cultivos con resultados, las características de los pacientes con bacterias prioritarias, así como el tipo de bacterias aisladas y los patrones de resistencia a los antibióticos. Resultados. De 25 469 hemocultivos realizados, se aislaron bacterias en 1628 (6%); 774 (48%) con agentes patógenos prioritarios de la OMS. La mayoría de las cepas bacterianas prioritarias aisladas (558; 72%) eran gramnegativas y 216 (28%), organismos grampositivos. La mayoría de los pacientes con bacterias priori- tarias (666; 86%) fueron hospitalizados en salas distintas de la unidad de cuidados intensivos, 427 (55%) eran varones y 321 (42%) tenían 60 años o más. De las 216 bacterias grampositivas aisladas, 205 (95%) eran Staphylococcus aureus. De las 558 bacterias prioritarias gramnegativas aisladas, las tres más comunes fueron Escherichia coli (34%), Klebsiella pneumoniae (28%) y Acinetobacter baumannii (20%). La mayor resistencia de Staphylococcus aureus fue a la oxacilina (41%). Entre las bacterias gramnegativas, la resistencia a los antibióticos varió del 4% (amikacina) al 72% (ampicilina). Conclusiones. El aislamiento de bacterias en los hemocultivos fue bajo y podría mejorarse. Se encontraron bacterias de la lista prioritaria de la OMS en todas las salas del hospital, por lo que es necesario aplicar rigurosas normas de prevención y control de infecciones y realizar una vigilancia continua de la resistencia a los antibióticos.Objetivos. Avaliar a suscetibilidade a antibióticos das bactérias consideradas prioritárias pela Organização Mundial da Saúde (OMS) (Acinetobacter baumannii, Escherichia coli, Klebsiella pneumoniae, Salmonella spp., Staphylococcus aureus e Streptococcus pneumoniae) em hemoculturas coletadas no hospital regional de Orinoquía na Colômbia. Métodos. Estudo transversal utilizando dados laboratoriais de rotina do período 2019-2021. Foram examinados os dados de amostras de sangue de pacientes com suspeita de infecção de corrente sanguínea. Determinamos o número total de hemoculturas realizadas e a proporção de culturas com rendimento, as características dos pacientes com bactérias prioritárias, e o tipo de bactéria isolada e padrões de resistência a antibióticos. Resultados. Das 25.469 hemoculturas realizadas, 1.628 (6%) foram positivas para bactérias, sendo que 774 (48%) dessas bactérias eram da lista de agentes patogênicos prioritários da OMS. A maioria das bactérias prioritárias isoladas (558; 72%) eram gram-negativas e 216 (28%) eram gram-positivas. A maioria dos pacientes com bactérias prioritárias (666; 86%) estava internada em enfermaria, e não em unidade de terapia intensiva. 427 (55%) eram homens e 321 (42%) tinham ≥ 60 anos de idade. Das 216 bactérias gram-positivas isoladas, 205 (95%) eram Staphylococcus aureus. Das 558 bactérias gram-negativas prioritárias isoladas, as três mais frequentes foram Escherichia coli (34%), Klebsiella pneumoniae (28%) e Acinetobacter baumannii (20%). O Staphylococcus aureus apresentou maior resistência à oxacilina (41%). Entre as bactérias gram-negativas, a resistência aos antibióticos variou entre 4% (amicacina) e 72% (ampicilina). Conclusões. O rendimento bacteriano das hemoculturas foi baixo e pode ser melhorado. As bactérias con-sideradas prioritárias pela OMS foram encontradas em todas as enfermarias do hospital. Os achados exigem normas rigorosas de prevenção e controle de infecção, e vigilância contínua da resistência bacteriana a antibióticos.Pan American Health OrganizationUnited States2024-02-29T18:45:12Z2024-02-29T18:45:12Z2023Artículo de revistahttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85Textinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 páginasapplication/pdfapplication/pdfSaavedra JC, Fonseca D, Abrahamyan A, Thekkur P, Timire C, Reyes J, et al. Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021. Rev Panam Salud Publica. 2023;47:e18. https://doi.org/10.26633/RPSP.2023.181680-5348https://www.dspace.uce.edu.ec/handle/25000/330431020-4989https://doi.org/10.26633/RPSP.2023.18reponame:Repositorio de la Universidad Central del Ecuadorinstname:Universidad Central del Ecuadorinstacron:UCEeng81Volmen 47, Numero 18Pan American Journal of Public HealthColombiaAl consultar y hacer uso de este recurso, está aceptando las condiciones de uso establecidas por los autores.Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)info:eu-repo/semantics/openAccess2024-12-11T10:06:09Zoai:dspace.uce.edu.ec:25000/33043Institucionalhttp://www.dspace.uce.edu.ec/Universidad públicahttps://www.uce.edu.ec/http://www.dspace.uce.edu.ec/oai.Ecuador...opendoar:24872024-12-11T10:06:09Repositorio de la Universidad Central del Ecuador - Universidad Central del Ecuadorfalse |
| spellingShingle | Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021 Saavedra, Julio C. Sepsis blood culture anti-bacterial agents drug resistance microbial |
| status_str | publishedVersion |
| title | Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021 |
| title_full | Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021 |
| title_fullStr | Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021 |
| title_full_unstemmed | Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021 |
| title_short | Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021 |
| title_sort | Bloodstream infections and antibiotic resistance at a regional hospital, Colombia, 2019–2021 |
| topic | Sepsis blood culture anti-bacterial agents drug resistance microbial |
| url | https://www.dspace.uce.edu.ec/handle/25000/33043 |