Evaluación del efecto analgésico y antiinflamatorio del aceite de cannabidiol (CBD) en caninos orquiectomizados
Orchiectomy is a procedure performed for population control purposes and partly for animal welfare, taking into account that this is a painful and unpleasant procedure for dogs, therefore, the objective of the present research is; to evaluate the analgesic and anti-inflammatory effect of cannabidiol...
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| Format: | bachelorThesis |
| Publicat: |
2025
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| Accés en línia: | https://dspace.ueb.edu.ec/handle/123456789/8514 |
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Afegir etiqueta | Sumari: | Orchiectomy is a procedure performed for population control purposes and partly for animal welfare, taking into account that this is a painful and unpleasant procedure for dogs, therefore, the objective of the present research is; to evaluate the analgesic and anti-inflammatory effect of cannabidiol (CBD) oil at different doses in orchiectomized canines. Methodologically, four treatments were established; T0: control, T1: 0.5 mg/kg, T2: 1 mg/kg and T3: 2 mg/kg of CBD, the effect of these doses was tested in 5 dogs older than 6 months of age congregated in the mentioned groups, to measure the effect of the CBD doses were evaluated, the neutrophil count before surgery, the pain by using the Glasgow veterinary scale at 2, 6 and 12 hours post-surgery, 6 and 12 hours after surgery, as well as neutrophil counts at 24 and 72 hours, the degree of inflammation at 24 and 72 hours after surgery, a serum biochemistry profile was also performed to determine the concentration of alkaline phosphatase (Fa), ALT, AST and albumin. The results determined that the administration of CBD maintained within the referential range the neutrophil count before and after surgery, in addition, it was proved that the three doses of CBD decreased the postoperative pain from 2 hours compared to the control group, additionally, it was evidenced that the dose of 2mg/kg of CBD (T3) caused a decrease in the degree of inflammation compared to what was observed in the patients of the control group and those who received the other proposed doses at 24 and 72 hours after surgery, the results of serum biochemistry showed that CBD administration is safe and does not cause hepatotoxicity since the administration of the doses under study did not influence the concentration of alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), However, it was recognized that the higher the dose administered, the greater the increase in albumin concentration, although this clinical finding is not influential in patients because it has no clinical support to determine hepatic dysfunction. We conclude that the administration of CBD in various doses is safe and can provide a good analgesic and anti-inflammatory effect in orchiectomized canines. |
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