Actividad Antiinflamatoria In Vitro de concentrados proteicos de maíz púrpura (Zea Mays) y fréjol rojo (phaseolus vulgaris) como medida paliativa al uso de medicamentos
The use of non-steroidal anti-inflammatory drugs (NSAIDs) constitutes the most important for the treatment of pre and post-operative processes. Although its effectiveness is proven, contraindications have been determined, especially the affection of the gastric mucosa. The use of plant foods with me...
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| Formato: | bachelorThesis |
| Idioma: | spa |
| Publicado em: |
2018
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| Acesso em linha: | http://dspace.ueb.edu.ec/handle/123456789/2985 |
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Adicionar Tag | Resumo: | The use of non-steroidal anti-inflammatory drugs (NSAIDs) constitutes the most important for the treatment of pre and post-operative processes. Although its effectiveness is proven, contraindications have been determined, especially the affection of the gastric mucosa. The use of plant foods with medicinal effects is in constant development, although there is little scientific evidence to verify the bio-activities attributed to these products. In this investigation, protein concentrates of purple corn and red beans were isolated to determine the anti-inflammatory activity, calculated from the percentage of inhibition compared with a commercial product (diclofenac). As a result of the isolation of proteins by isoelectric point, the concentrates obtained showed significant differences in one of the treatments, which determines the importance of the pH on the efficiency of the extraction process. Once the in vitro anti-inflammatory activity was performed, the maximum inhibition percentage obtained at pH 8.0-5.0 for purple corn was 68.75% Vs. 41.67 of the commercial product (diclofenac 100 mg). In the case of red beans, the maximum percentage of inhibition was 50% at pH 8.0-4.0 and 8.0-6.0, also exceeding the percentage of inhibition of the standard used. Although the results of this investigation show that the ancestrally used plant products possess an important anti-inflammatory activity, it is necessary to clarify that, although they can not be considered as a definitive replacement to the use of commercial medicines, if they can be considered as nutritional supplements that contribute to the treatment of conditions with inflammatory processes. Further studies at the molecular level of protein characterization and in vivo tests are recommended to counteract the results obtained. Key words: Purple corn, red beans, proteins, diclofenac, anti-inflammatory activity, in vitro. |
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