Anemia drepanocítica, manifestaciones clínicas y diagnóstico de laboratorio.
Sickle cell anemia is a group of chronic disorders caused by autosomal recessive disorders in which hemoglobin S (Hb S) is present in red blood cells. This pathology appears by a spontaneous mutation on chromosome 11, in which a glutamic acid is replaced by a valine at position 6 of the globin beta...
Kaydedildi:
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| Diğer Yazarlar: | |
| Materyal Türü: | bachelorThesis |
| Dil: | spa |
| Baskı/Yayın Bilgisi: |
2024
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| Online Erişim: | http://dspace.unach.edu.ec/handle/51000/12362 |
| Etiketler: |
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Etiketle | Özet: | Sickle cell anemia is a group of chronic disorders caused by autosomal recessive disorders in which hemoglobin S (Hb S) is present in red blood cells. This pathology appears by a spontaneous mutation on chromosome 11, in which a glutamic acid is replaced by a valine at position 6 of the globin beta chain. Information was collected through a bibliographic review based on the observation and analysis of the last ten-year publications with a qualitative descriptive level approach and its non-experimental design. We selected 31 articles in indexed databases like Google Academic, ProQuest, Redalyc, Elsevier, SciELO, and Pubmed. It was found that the most frequent clinical manifestations that occur in patients with this pathology are Vasooclusive seizures in 94.44%, divided into thoracic, abdominal, and bone, followed by general signs and symptoms such as pale, dyspnea, fatigue, jaundice, weakness, tiredness and tachycardia in 38.88%. Finally, the most widely used laboratory test was hemoglobin in 76.92%, with the joint application of the 2% sodium metabisulfite test in 46.15% to observe the sickle shape of red blood cells. As a confirmatory test, the use of hemoglobin electrophoresis with 46.15% is recommended, which allows the diagnosis of patients with HB S. |
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