El eje microbiota-intestino-cerebro y su implicación en la depresión.
Depression is a mental illness that affects millions of people worldwide, profoundly impacting their emotional well-being and quality of life. Recent research has highlighted the importance of the gut-brain axis in the development and progression of depression. This bidirectional communication syste...
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| Format: | bachelorThesis |
| Jezik: | spa |
| Izdano: |
2024
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| Online pristup: | http://dspace.unach.edu.ec/handle/51000/13530 |
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Dodaj oznaku | Sažetak: | Depression is a mental illness that affects millions of people worldwide, profoundly impacting their emotional well-being and quality of life. Recent research has highlighted the importance of the gut-brain axis in the development and progression of depression. This bidirectional communication system involves the gut microbiota, the enteric nervous system, and the central nervous system. This complex interaction shows that the gut microbiome can significantly influence brain function and mood. A bibliographic review was conducted on the role of the gut-brain axis in depression, aiming to better understand the underlying mechanisms and potential therapeutic interventions. The study analyzed molecular mechanisms and signaling pathways connecting the gut microbiota to brain function. Additionally, a comparative analysis of bacterial phyla presents in the intestines of healthy patients and those with depression was performed. The review also explored the use of probiotics and prebiotics as potential treatments for depression. For this review, 110 documents published in the last five years were included, of which 25 were selected for detailed analysis. The review was conducted using high-impact databases (Latindex, Lilacs, Scielo, Redalyc, Scopus, Medline, PubMed, and Ice Web of Science) and employed Boolean operators and health descriptors to ensure an exhaustive and relevant search. The results of this review indicate a strong association between gut microbiota and depression, highlighting key molecular mechanisms and signaling pathways involved. Furthermore, studies suggest alterations in the composition of the microbiota in patients with depression compared to healthy patients. Additionally, evidence shows that the use of probiotics and prebiotics present a promising strategy for managing depression, although more research is needed to fully understand their efficacy and the mechanisms involved. |
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