Pruebas de laboratorio y caracterización clínica para el diagnóstico de Lupus Eritematoso.

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that can affect various systems of the body. In Ecuador, as well as in many other countries, SLE is a condition that affects a significant portion of the population, with a prevalence of 40 cases per 100,000 inhabitants. The aim of this research was to clinically characterize and identify the most commonly used laboratory tests for the accurate determination of SLE. Methodologically, the tests used in diagnosing the condition were distinguished through bibliographic analysis, highlighting the clinical findings and age groups of patients with this disease through the review of scientific articles. The results indicated that different antibodies prevail in patients with SLE in the mentioned studies. It is observed that the positivity rates vary significantly, ranging from around 40% to almost 100%. Regarding antinuclear antibodies (ANA), a positivity range from 40.4% to 98.2% was found. Additionally, in relation to anti-DNA antibodies, a positivity range from 17.2% to 88.5% was determined. Furthermore, there was a heterogeneity of clinical manifestations, ranging from cutaneous symptoms to severe complications such as renal insufficiency and neurological diseases. It was also determined that it may have implications during pregnancy. In conclusion, these data highlight the importance of considering the variability in antibody findings when diagnosing and treating these diseases, which can help doctors adapt their clinical approach for each patient effectively.

• Glavni autor: Zurita López, Alex Robinson (author)
• Format: bachelorThesis
• Jezik: spa
• Izdano: 2024
• Teme: Lupus Eritematoso; Diagnóstico; Manifestaciones clínicas; Autoinmune
• Online pristup: http://dspace.unach.edu.ec/handle/51000/13392