Actividad biologica de extractos acuosos obtenidos a partir de semillas de achotillo y taxo

ABSTRACT: Bacterial resistance to antibiotics being an increasing public health problem worldwide, the aim of this project was to determine the biological activity of aqueous extracts obtained from the seeds of Taxo (Passiflora tripartita) and Achotillo (Nephelium lappaceum). The aqueous extracts were obtained by mechanical disruption using 15mL of sterile physiological saline. The biological activity of the aqueous extracts was determined by determining their ability to agglutinate suspended erythrocytes of human blood groups A, B, and O, the anticoagulant activity was determined by assessing the activity of the extracts on plasma coagulation proteins in platelet-poor plasma measured by TP and TTPa, the antibacterial activity of the extracts was determined by inhibiting the growth of ATCC bacterial strains. Cytotoxic activity was assessed by determining the lethal dose fifty of the extracts on Artemia salina nauplii. The results revealed that the Taxo extract possesses the ability to agglutinate human erythrocytes non-selectively. Achotillo and Taxo extracts were shown to have anticoagulant action by lengthening TP and TTPa. They also possess antibacterial activity on Staphylococcus aureus strain, while only Taxo extract showed activity against Proteus mirabilis strain. In terms of cytotoxic activity, both extracts were found to be non-toxic. It can be concluded that the seeds of Taxo and Achotillo possess: haemagglutinating, anticoagulant, antibacterial activity, and no cytotoxicity. Keywords: lectins, "biological activity", "haemagglutinin", antibacterial, anticoagulant.

• Autor principal: Martínez Carrasco, Jonathan Edward (author)
• Altres autors: Vela Jiménez, Jhonny Bladimir (author)
• Format: bachelorThesis
• Idioma: spa
• Publicat: 2023
• Matèries: lectinas; hemoaglutinina; antibacterianos; anticoagulantes
• Accés en línia: http://dspace.unach.edu.ec/handle/51000/11296