Avances en el tratamiento de la Artritis Reumatoide. Terapias biológicas y de moléculas pequeñas.

The study aimed to identify advancements in the treatment of rheumatoid arthritis, focusing on biological therapies and small molecules through a bibliographic review. A descriptive and retrospective review of scientific literature published in the last ten years, in both English and Spanish, was conducted. The search was conducted using Boolean operators and specific keywords in the PubMed, Google Scholar, and Elsevier Library databases. From a total of 74 identified articles, a final sample of 29 studies was selected after a detailed review of abstracts and full texts. The selected studies were organized into a table for analysis. The reviewed studies indicated that biological therapies, such as abatacept and sarilumab, are highly effective in treating refractory rheumatoid arthritis, achieving significant remission, and improving clinical symptoms. Similarly, small molecules, such as JAK inhibitors, demonstrated high effectiveness and significantly improved patient quality of life, making them a viable alternative to traditional biological therapies. However, JAK inhibitors showed a higher risk of infections. Both biological therapies and small molecules have proven to be effective in managing refractory rheumatoid arthritis, with the former standing out for their potent action and JAK inhibitors offering high efficacy and more excellent tolerability in some cases.

• Main Author: Almache Alulema, Erika Sthefania. (author)
• Other Authors: Cuenca Guerrero, Paul Marcelo (author)
• Format: bachelorThesis
• Language: spa
• Published: 2024
• Subjects: Terapias biológica; Artritis Reumatoide; Inhibidores de las Cinasas Janus; Eficacia; Seguridad
• Online Access: http://dspace.unach.edu.ec/handle/51000/14047