Fundamentos genéticos que modulan el desarrollo de preeclampsia-eclampsia.

The systematic review on the genetic foundations of preeclampsia-eclampsia reveals that this gestational complication has a complex genetic and epigenetic basis, involving genes related to placental function, angiogenesis, and inflammation (such as STOX1, FLT1, and ENG), as well as microRNA dysregulation. Key animal models and biomarkers such as sFlt-1/PlGF and ELABELA were identified as promising tools for early diagnosis, although challenges remain in standardization and clinical implementation due to the heterogeneity of studies and genetic variability across populations. The methodology consisted of a descriptive study with a qualitative approach, based on a systematic review of the scientific literature. The search was conducted in high-impact biomedical databases (PubMed, MEDLINE, Cochrane Library, Scopus, and Web of Science), applying inclusion and exclusion criteria to select relevant studies published since 2019, mostly in English, but also in Spanish, Portuguese, Chinese, and Russian. These findings offer new opportunities for personalized management of preeclampsia but require validation in more diverse populations. Future research should focus on integrating these genetic and epigenetic markers into clinical protocols to improve early diagnosis, treatment, and maternal-fetal outcomes.

• Glavni autor: Masache Sanchez, Deyvis Jhardel (author)
• Format: bachelorThesis
• Jezik: spa
• Izdano: 2025
• Teme: Preeclampsia; Eclampsia; Genética; Epigenética; Biomarcadores
• Online pristup: http://dspace.unach.edu.ec/handle/51000/15730