Estimulación cerebral profunda en el tratamiento de los síntomas motores del parkinson
Introduction: The disease of Parkinson is developed due to degeneration of dopaminergic neurons in the substantia nigra pars where it is compacted, which manifests itself in the appearance of motor symptoms such as: bradykinesia, resting tremor, rigidity and postural instability; as well as non - mo...
محفوظ في:
| المؤلف الرئيسي: | |
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| التنسيق: | bachelorThesis |
| اللغة: | spa |
| منشور في: |
2025
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://dspace.uniandes.edu.ec/handle/123456789/18732 |
| الوسوم: |
إضافة وسم
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إضافة وسم | الملخص: | Introduction: The disease of Parkinson is developed due to degeneration of dopaminergic neurons in the substantia nigra pars where it is compacted, which manifests itself in the appearance of motor symptoms such as: bradykinesia, resting tremor, rigidity and postural instability; as well as non - motor symptoms such as gastrointestinal, sleep, autonomic, cognitive, among others, which reflect the involvement of different non - dopaminergic pathways. The diagnosis is based on its most characteristic clinical manifestations and excludes other causes of parkinsonism. Pharmacological treatment seeks to control motor and non - motor symptoms, which worsen due to the natural history of the disease or are accompanied by complications due to therapy, making other interventions such as deep brain stimulation necessary. Objective: For this reason, the present study aimed to review the therapeutic indications based on the assessment of the effectiveness, safety and cost - effectiveness of DBS in disorders of Parkinson from its therapeutic potential demonstrated by current scientific evidence. Methodology: The present research assumes a qualitative type modality, taking into account that it is a literature review article where only the analysis of documents will be applied as an empirical level scientific method. Results: The therapeutic indications were reviewed from the assessment of the effectiveness, safety and cost - effectiveness of DBS in disorders of Parkinson from its therapeutic potential demonstrated with current scientific evidence. Conclusions: It was concluded that there is consistent and robust evidence of the efficacy of DBS in reducing motor symptoms, medication complications and medication dosage, as well as improving functionality and quality of life of PD patients. |
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