Anticoagulación tras evento cerebrovascular isquémico cardioembólico

Background: The “1-3-6-12 day rule” for applying ACOD in patients with AF after ischemic stroke indicates early/late times that differ from those used in clinical practice according to neurological severity. There are few concrete-reliable medical registries of anticoagulation. Introduction: Cerebrovascular events are essential substrate instability for ischemic-hemorrhagic processes. Main cause AF includes age, sex, hypertension, diabetes, CAA, obesity-reducing OACs, bleeding, thrombus, embolism, etc. Objective: To determine the optimal time to initiate anticoagulation after an ischemic cerebrovascular event of cardioembolic origin through an updated literature review. Methods: This study consisted of systematic literature review PubMed and Cochrane, data acquired from registries, Japan; SAMURAI (September 2011-March 2014) and RELAXED (February 2014-April 2016). 1797 patients (referral), classified into two groups; early (N=785) and late (N=1012). Recurrent CVD/systemic embolism, ischemic CVD and major bleeding within 90 days were included. Results: 1797 patients started OACD administration 2 days after TIA and 3, 4 and 5 days after mild, moderate and severe CVD. CVD/systemic embolism was less common in the early group (1.9%), but relevant in the late group (3.9%), as well as ischemic CVD (1.7%; 3.2%). Major bleeding was similar in both groups (0.8%; 1.0%). Ischemic CVD (2.4 %; 2.2 %) and intracranial hemorrhage (0.2 %; 0.6 %) were common (validation). Conclusions: The application of ACOD and “1-2-3-4-day rule” proved feasible to reduce CVD risk and avoid major bleeding. Underdosing, adherence and anticoagulation time according to severity provided findings to improve medical practice after CVD.

• Auteur principal: Muñoz Tejada, Karla Mishell (author)
• Format: bachelorThesis
• Langue: spa
• Publié: 2025
• Sujets: EVENTO CEREBROVASCULAR; FIBRILACIÓN AURICULAR; ANTICOAGULANTES; HEMORRAGIA; WARFARINA; DABIGATRÁN; RIVAROXABÁN; APIXABÁN
• Accès en ligne: https://dspace.uniandes.edu.ec/handle/123456789/19745