Propóleo en la prevención de mucositis oral en pacientes oncológicos que reciben quimioterapia o radioterapia: una revisión sistemática

Background: Oral mucositis (OM) is an inflammatory and ulcerative reaction of the oral mucosa and the gastrointestinal tract, as a disabling adverse effect in patients receiving oncological treatment with chemotherapy or radiotherapy. Objective: to perform an updated systematic review on the efficacy of propolis in the prevention and treatment of oral mucositis in oncological patients receiving chemotherapy or radiotherapy. Methodology: This is a systematic review of randomized, placebo-controlled clinical trials, performed in the biomedical databases Pubmed, Web of Science and Google Scholar, using the PRISMA protocol. Results: After the search, nine clinical trials were included, with a total sample of 513 subjects included, of which 239 subjects received propolis and 274 received placebo. The severity of OM was shown to be lower in the group receiving propolis during the second (p = 0.027) and third week (p = 0.039), and at the end of the third week, most of the patients receiving propolis were asymptomatic (P = 0.001), and propolis showed less severity of grade 2 dysphagia (46.66% vs 86.66%) and grade 3 (6.66% vs 53.33%) compared to placebo (p = 0.01). Conclusion: Propolis reduced the severity of OM from the second week onwards, and also demonstrated superiority in dysphagia and its severity compared to placebo. The incidence of OM, oral burning sensation and frequency of candidiasis were reduced. There was also improvement in chewing, easy swallowing, adherence and tolerability of the product compared to placebo.

• Autor principal: Palacios Morales, Luis David (author)
• Formato: bachelorThesis
• Idioma: spa
• Publicado em: 2025
• Assuntos: ESTOMATITIS; PROPÓLEO; NEOPLASIAS; MUCOSITIS ORAL
• Acesso em linha: https://dspace.uniandes.edu.ec/handle/123456789/19189