Artritis reumatoidea y factores que influyen en la eficacia del tratamiento farmacológico

Rheumatoid arthritis (RA) is a chronic inflammatory disease that significantly affects patients' quality of life. Its management is complicated by the diversity of responses to treatment, which are influenced by genetic, environmental and lifestyle factors. Objective: to carry out an updated bibliographic review of the main factors that influence the efficacy of pharmacological treatment of rheumatoid arthritis, in order to improve the quality of life of these patients. Methods: a descriptive study was carried out by means of a bibliographic review, in which several scientific sources were examined, including results of varied researches, linked to the subject in question and which clearly demonstrate the existence of this problem. Results: genetic variations in alleles such as HLA-DRB1, PTPN22, and STAT4 are crucial for predisposition and response to treatment in patients with RA. These genetic differences affect the efficacy of disease-modifying drugs (csDMARDs), biologic therapies (bDMARDs), and targeted therapies (tsDMARDs). In addition, lifestyle, including smoking, diet, and obesity, was found to have a significant impact on treatment response. Conclusions: This study has demonstrated that both genetic characteristics and lifestyle factors should be considered that could significantly improve the therapeutic outcomes and quality of life of RA patients. This is suggestive of the need to provide personalized treatment in this pathology, as well as to continue investigating the genetic diversity of each subject.

• Hovedforfatter: Rocha Vega, Jonathan Ramiro (author)
• Format: bachelorThesis
• Sprog: spa
• Udgivet: 2024
• Fag: ARTRITIS REUMATOIDE; FARMACOGENÉTICA; GENÉTICA; TERAPIAS BIOLÓGICAS; TRATAMIENTO PERSONALIZADO
• Online adgang: https://dspace.uniandes.edu.ec/handle/123456789/18679