Péptido C como indicador de reserva pancreática en los pacientes diabéticos tipo 2 del hospital del día en Zamora

The diabetes mellitus type 2 is a chronic progressive disease in which hyperglycemia occurs due to insulin deficiency and resistance to this hormone in muscles, that eventually causes failure in the functioning of pancreatic cells β. One of the most useful markers for determining endogenous insulin secretion is C-peptide, which is secreted along with insulin in equimolar concentrations, which unlike insulin, is more specific for measuring pancreatic reserve. The present research aimed to determine the C-peptide in 115 patients diagnosed with diabetes mellitus type 2 treated in the Day Hospital of the canton Zamora. In addition, they completed a survey in order to correlate whether the levels of C-peptide measured in plasma serum are adequate, as well as whether the duration of the disease affects the pancreatic reserve. After statistical analysis, C-peptide levels were normal at 53.9 %, elevated in a 34.8 % and decreased in a 11.3 %, that demonstrates a higher prevalence of patients with preserved pancreatic reserve. It was also evident that the pancreatic reserve is lost as the disease progresses. However, there comes a cut-off point where the cells can stabilize. Likewise, the determinations of peptide with respect to sex were analyzed, the sample was represented mostly by the male sex that retain much of its endogenous insulin reserve. In relation to age, there was no statistically significant difference that demonstrates that there is a relationship between the decrease in pancreatic reserve and age

• Hoofdauteur: Gordillo Gordillo, Nikole Dayana (author)
• Formaat: bachelorThesis
• Taal: spa
• Gepubliceerd in: 2022
• Onderwerpen: LABORATORIO CLÍNICO; DIABETES MELLITUS; PÉPTIDO C; RESERVA PANCREÁTICA
• Online toegang: https://dspace.unl.edu.ec/jspui/handle/123456789/25698