miARNs asociados a leucemia linfoblástica aguda como herramienta diagnóstica y pronóstica en pacientes pediátricos. Una revisión sistemática
Acute lymphoblastic leukemia (LLA) is one of the most frequent neoplasms in pediatrician patients because of its heterogeneity, high rate of relapse, mortality, and resistance to multiple medications. The deletions, translocations, and gene rearrangements are its main causes, as posttranscriptional...
Պահպանված է:
| Հիմնական հեղինակ: | |
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| Ձևաչափ: | bachelorThesis |
| Լեզու: | spa |
| Հրապարակվել է: |
2024
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| Խորագրեր: | |
| Առցանց հասանելիություն: | https://dspace.unl.edu.ec/jspui/handle/123456789/29335 |
| Ցուցիչներ: |
Ավելացրեք ցուցիչ
Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
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Ավելացրեք ցուցիչ | Ամփոփում: | Acute lymphoblastic leukemia (LLA) is one of the most frequent neoplasms in pediatrician patients because of its heterogeneity, high rate of relapse, mortality, and resistance to multiple medications. The deletions, translocations, and gene rearrangements are its main causes, as posttranscriptional modifications originate from miRNAs that regulate the cell process, development, and progress of LLA. The objective of this revision was to search the miRNA associated with LLA emphasizing its diagnosis and prognosis with pediatric patients. The methodology used was the PRISMA model systematic information research, including nineteen articles, ten cohort studies, four experimentations, two transversal, and two cases and controls. All of these with a total of 1029 pediatric patients. It verified the bias risk of each study through the JBI tool (Joanna Bridgge’s Institute), and the systematic revision of quality with the PRIMAS tool (Preferred Reporting Items for Systematic Review and Meta-Analysis). As a result, thirty-nine miRNAs were studied. Some were regulated according to their increase like miR-181a, miR-149, miR155, and miR146a, which genes are direct from EGT1a, JunB, ZNF238, and STAT1, respectively, were regulated to its decrease, others were its expression was reduce got associate with the regulation of some oncogenes. The miRNAs selected to evaluate the diagnostic value showed high sensibility and specificity, while others, with expression reduced associated with the lack of regulation of some oncogenes. The miRNAs selected to evaluate the diagnostic showed a high sensibility and specificity; miR-125b-1 and miR-203 constituted efficient circulating data; miR28-3p and miR378a-3p stand out with AUC-ROC>80%; miR638 and miR-92a combined show discriminative potential; while miR-146 was the best biomarker diagnostic with AUC-ROC of 1. On the other hand, to analyse the outlook it was checked that miR-100 express going down and miR-210 express to up, were associated with a bad diagnosis; miR221 and miR-21 overexpressed given survival rates shorter, as general survival (SV), as free of illness (DFS); miR-92a and miR638 were forms of a bad diagnosis, while miR146a- reduce in LLA posttreatment arrive a good prognostic. In conclusion, some miARNS take part in the genetical in pediatric LLA, in which positive or negative regulation modulates certain genes whether they are of tumors like oncogenes. Multiple miARNS present a potential diagnosis with a high sensibility and specificity, highlighting miR-146a. While the overexpression of miR-100, miR-221, miR-21, miR-326, among others, were pointers of a bad diagnosis, comparing the reduction of miR-146a associate with a good prognosis in pediatric LLA. Keyboards: Leukemia; cancer; miRNA; diagnosis; prognosis; pediatrics |
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