Colistin resistencia en Enterobacteriaceae productoras de carbapenemasas aisladas de pacientes hospitalizados

The mechanisms of acquired and transmissible resistance consist fundamentally in the production of bacterial enzymes that inactivate antibiotics. Some bacteria can develop several resistance mechanisms against one or many antibiotics, and in the same way an antibiotic can be inactivated by different mechanisms. Some factors such as self-medication, unnecessary prescription, non-compliance with prescribed treatments and the consumption of antibiotic residues in foods of animal origin predispose to the appearance of super bacteria capable of expressing resistance to multiple families of drugs. For this reason, the present work was carried out to identify the colistin resistance genes in isolated carbapenemase-producing strains of hospitalized patients in a second-level hospital during 2019, it was a study with a quantitative approach with a descriptive-cross-sectional design in which We worked with 32 carbapenemaseproducing Enterobacteriaceae strains that were screened for the mcr 1, mcr 2, mcr 3, mcr 4 and mcr 5 genes, the mcr 2 and mcr 5 genes were identified in the Citrobacter freundii bacteria and Klebsiella oxytoca. Demonstrating the circulation of multiresistant strains that inactivate betalactams and colistin, the latter antibiotic being considered as a combined therapy option in carbapenemase-producing strains.

• Hlavní autor: Allison Loretho, Ochoa Paz (author)
• Médium: bachelorThesis
• Jazyk: spa
• Vydáno: 2022
• Témata: FÁRMACORRESISTENCIA BACTERIANA; LABORATORIO CLÍNICO; COLISTINA; ENTEROBACTERIACEAE
• On-line přístup: https://dspace.unl.edu.ec/jspui/handle/123456789/24555