Revisión sistemática. comportamiento epidemiológico de las infecciones hospitalarias por Klebsiella pneumoniae en adultos de Latinoamérica

Nosocomial infections, also known as healthcare-associated infections (HAIs), is one of the leading causes of death globally among hospitalized patients. Klebsiella pneumoniae represents a serious threat to people under medical conditions in hospitals, due to its unique ability to acquire multidrug resistance. The association of several antibiotic resistance, virulence, and risk factors contributes to higher rates of morbidity and mortality in hospital settings. The objective of this paper is to review data on the epidemiological behavior of hospital infections due to Klebsiella pneumoniae, the mortality rate and its relationship with the most common resistance mechanisms found in adult patients in Latin America. Thus, it was performed a systematic review of the bibliography in the following databases Pubmed, ELSERVER, Scielo and LILACS, with a retrospective and descriptive research design, based on the Cochrane system. For the sifting, the PRISMA method was employed, which included 10 studies made in Latin America, published in the period 2013-2023 about adult patients hospitalized with nosocomial infections. According to it, we may indicate that the in-hospital mortality rate of K. pneumoniae in Latin America is 45.1%; the resistance mechanisms found were ESBLs with a median of 44.13%, and KPC with a median of 40%; The mortality rate in regards to the resistance mechanism was higher for KPC (46.6%) than for ESBLs (30%). Ultimately, in-hospital mortality from K. pneumoniae is closely tied to enzyme inhibition resistance mechanisms such as ESBLs and KPC, and is also determined by risk factors such as: self-medication, previous use of antibiotics, recurrent infections, comorbidities, underlying diseases, immunosuppression, length of hospitalization and hospital treatment

• Autor Principal: Vaca Carrión, Cristina Nicole (author)
• Formato: bachelorThesis
• Idioma: spa
• Publicado: 2024
• Subjects: LABORATORIO CLÍNICO; INFECCIÓN HOSPITALARIA; KLEBSIELLA PNEUMONIAE
• Acceso en liña: https://dspace.unl.edu.ec/jspui/handle/123456789/29399