Efecto de la administración de meloxicam en la fase periovulatoria de yeguas.

Ovulation is an inflammatory physiological process in which prostaglandins (PGE and PGF) play an important role. Nonsteroidal anti-inflammatory drugs, by inhibiting cyclooxygenases, can influence the ovulatory phase of mares. The aim of this study was to evaluate the effect of meloxicam administration on the ovulation rate of mares. Ten cyclic crossbreed mares between 7 to 15 years old and body condition of 4 were used; ultrasonography was used to monitor follicular development, in the presence of a follicle ≥35 mm and grade 2 to 3 endometrial edema, one of the following treatments was randomly applied: hCG (2,500IU of hCG (Fertcor®, Ceva, Brazil) IV) or hCG + Meloxicam (2,500IU of hCG IV + 0.6 mg/kg (Meloxisan®, Montana, Peru) IM) with the induction and every 24 hours until the time of ovulation). Subsequently, ovulation was verified at 36, 42 and 48 hours after induction. Statistical analysis was performed using PROC MIXED models and chi-square test (SAS on Demand for Academics 2023). All mares ovulated within the estimated time post induction (48 h); however, there was a trend (p=0.07) of treatment effect over time, where mares on meloxicam treatment together with hCG tended to ovulate in longer time (42.00 ±1.14 hrs) compared to applying hCG alone (39.00 ±1.14 hrs). There was no interference of treatment, side, or interaction of treatment by side on the size of the preovulatory follicle, in mares induced with hCG the follicle measured 38.50 ±0.84 mm and with hCG+meloxicam it measured 40.00±0.94 mm. The use of meloxicam at therapeutic dose and frequency in the periovulatory stage does not interfere with the ovulation rate of hCG-induced mares.

• Main Author: Paqui Vega, Yarina Del Cisne (author)
• Format: bachelorThesis
• Language: spa
• Published: 2024
• Subjects: OVULACION; ULTRASONOGRAFIA; PROSTAGLANDINA
• Online Access: https://dspace.unl.edu.ec/jspui/handle/123456789/29670