Resistencia antimicrobiana en enterobacterias productora de β-lactamasas de espectro extendido blee aislada de aguas residuales.
Antimicrobial resistance caused by extended-spectrum β-lactamase (ESBL) producing enterobacteria in wastewater represents a critical public health problem worldwide. The presence of antibiotics and pathogenic microorganisms in untreated wastewater, especially those from clinical settings, creates id...
Kaydedildi:
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| Materyal Türü: | masterThesis |
| Dil: | spa |
| Baskı/Yayın Bilgisi: |
2024
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| Konular: | |
| Online Erişim: | https://repositorio.uta.edu.ec/handle/123456789/42944 |
| Etiketler: |
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Etiketle | Özet: | Antimicrobial resistance caused by extended-spectrum β-lactamase (ESBL) producing enterobacteria in wastewater represents a critical public health problem worldwide. The presence of antibiotics and pathogenic microorganisms in untreated wastewater, especially those from clinical settings, creates ideal conditions for the development and dissemination of resistant bacterial strains, which amplifies the risk of spreading multidrug-resistant infections. In this context, a quasi-experimental, cross-sectional and descriptive study was carried out, whose objective was to analyze antimicrobial resistance in ESBL-producing enterobacteria isolated from wastewater collected from a high-complexity clinical laboratory. For this purpose, 16 wastewater samples were collected, which were processed following the guidelines established in the NTE INEN 2169:2013 Standard. Microbiological identification of ESBL producing enterobacteria was carried out using the CHROMagar BLEE differential culture medium, and antimicrobial resistance patterns were assessed using the Sensititre plate for Gram-negative bacteria. Of the samples analyzed, 37.6% (n=6) were positive for ESBL-producing enterobacteria, with Escherichia coli being the most frequently isolated species, with 57.1% of cases (n=4), followed by Pseudomonas sp, Klebsiella sp and Enterobacter sp. High resistance to third-generation cephalosporins and monobactams was observed, which shows the ability of these bacteria to evade common antimicrobial treatments. The results of this study indicate that wastewater from clinical laboratories contains a significant amount of ESBL-producing enterobacteria with multimicrobial resistance, which constitutes a latent risk for public health. In response to this problem, it is imperative to develop and implement a manual of procedures for the proper management and treatment of wastewater in these environments, in order to prevent the spread of resistant microorganisms and protect both public health and the environment, thus reducing the dissemination of multi resistant pathogens in the community. |
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