Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in Ecuador
Natural products are one of the main sources for developing new drugs. The alkaloids obtained from the plant family Amaryllidaceae have interesting structures and biological activities, such as acetylcholinesterase inhibition potential, which is one of the mechanisms used for the palliative treatmen...
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| Formato: | article |
| Idioma: | eng |
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2021
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| Acesso em linha: | https://www.mdpi.com/2223-7747/10/12/2686/html https://hdl.handle.net/20.500.14809/3160 |
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| author | Tallini, Luciana R. |
| author2 | Carrasco, Angelo Acosta León, Karen Vinueza, Diego Bastida, Jaume Oleas, Nora |
| author2_role | author author author author author |
| author_facet | Tallini, Luciana R. Carrasco, Angelo Acosta León, Karen Vinueza, Diego Bastida, Jaume Oleas, Nora |
| author_role | author |
| collection | Repositorio Universidad Tecnológica Indoamérica |
| dc.creator.none.fl_str_mv | Tallini, Luciana R. Carrasco, Angelo Acosta León, Karen Vinueza, Diego Bastida, Jaume Oleas, Nora |
| dc.date.none.fl_str_mv | 2021 2022-06-19T03:04:21Z 2022-06-19T03:04:21Z |
| dc.identifier.none.fl_str_mv | https://www.mdpi.com/2223-7747/10/12/2686/html https://hdl.handle.net/20.500.14809/3160 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Plants. Volume 10, Issue 12 |
| dc.rights.none.fl_str_mv | https://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositorio Universidad Tecnológica Indoamérica instname:Universidad Tecnológica Indoamérica instacron:UTI |
| dc.title.none.fl_str_mv | Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in Ecuador |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | Natural products are one of the main sources for developing new drugs. The alkaloids obtained from the plant family Amaryllidaceae have interesting structures and biological activities, such as acetylcholinesterase inhibition potential, which is one of the mechanisms used for the palliative treatment of Alzheimer’s disease symptoms. Herein we report the alkaloidal profile of bulbs and leaves extracts of Crinum × amabile collected in Ecuador and their in vitro inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. Using Gas Chromatography coupled to Mass Spectrometry (GC-MS), we identified 12 Amaryllidaceae alkaloids out of 19 compounds detected in this species. The extracts from bulbs and leaves showed great inhibitory activity against AChE and BuChE, highlighting the potential of Amaryllidaceae family in the search of bioactive molecules. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UTI_b76e427a913badeaae09a2fac4c31acf |
| instacron_str | UTI |
| institution | UTI |
| instname_str | Universidad Tecnológica Indoamérica |
| language | eng |
| network_acronym_str | UTI |
| network_name_str | Repositorio Universidad Tecnológica Indoamérica |
| oai_identifier_str | oai:repositorio.uti.edu.ec:20.500.14809/3160 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | Plants. Volume 10, Issue 12 |
| reponame_str | Repositorio Universidad Tecnológica Indoamérica |
| repository.mail.fl_str_mv | . |
| repository.name.fl_str_mv | Repositorio Universidad Tecnológica Indoamérica - Universidad Tecnológica Indoamérica |
| repository_id_str | 0 |
| rights_invalid_str_mv | https://creativecommons.org/licenses/by/4.0/ |
| spelling | Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in EcuadorTallini, Luciana R.Carrasco, AngeloAcosta León, KarenVinueza, DiegoBastida, JaumeOleas, NoraNatural products are one of the main sources for developing new drugs. The alkaloids obtained from the plant family Amaryllidaceae have interesting structures and biological activities, such as acetylcholinesterase inhibition potential, which is one of the mechanisms used for the palliative treatment of Alzheimer’s disease symptoms. Herein we report the alkaloidal profile of bulbs and leaves extracts of Crinum × amabile collected in Ecuador and their in vitro inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes. Using Gas Chromatography coupled to Mass Spectrometry (GC-MS), we identified 12 Amaryllidaceae alkaloids out of 19 compounds detected in this species. The extracts from bulbs and leaves showed great inhibitory activity against AChE and BuChE, highlighting the potential of Amaryllidaceae family in the search of bioactive molecules.Plants. Volume 10, Issue 122022-06-19T03:04:21Z2022-06-19T03:04:21Z2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://www.mdpi.com/2223-7747/10/12/2686/htmlhttps://hdl.handle.net/20.500.14809/3160enghttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessreponame:Repositorio Universidad Tecnológica Indoaméricainstname:Universidad Tecnológica Indoaméricainstacron:UTI2022-06-20T20:40:41Zoai:repositorio.uti.edu.ec:20.500.14809/3160Institucionalhttps://repositorio.uti.edu.ec/Institución privadahttps://indoamerica.edu.ec/https://repositorio.uti.edu.ec/oai.Ecuador...opendoar:02022-06-20T20:40:41Repositorio Universidad Tecnológica Indoamérica - Universidad Tecnológica Indoaméricafalse |
| spellingShingle | Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in Ecuador Tallini, Luciana R. |
| status_str | publishedVersion |
| title | Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in Ecuador |
| title_full | Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in Ecuador |
| title_fullStr | Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in Ecuador |
| title_full_unstemmed | Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in Ecuador |
| title_short | Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in Ecuador |
| title_sort | Alkaloid profiling and cholinesterase inhibitory potential of crinum × amabile donn. (amaryllidaceae) collected in Ecuador |
| url | https://www.mdpi.com/2223-7747/10/12/2686/html https://hdl.handle.net/20.500.14809/3160 |