Multiple Effects of Berberine Derivatives on Colon Cancer Cells
The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit this interesting feature, we synthesized three berberine derivatives, namely, NAX012, NAX014, and NAX...
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| Materyal Türü: | article |
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2014
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| Online Erişim: | http://dspace.utpl.edu.ec/handle/123456789/19110 |
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Etiketle | _version_ | 1839966616098439168 |
|---|---|
| author | Guaman Ortiz, L. |
| author_facet | Guaman Ortiz, L. |
| author_role | author |
| collection | Repositorio Universidad Técnica Particular de Loja |
| dc.creator.none.fl_str_mv | Guaman Ortiz, L. |
| dc.date.none.fl_str_mv | 18/06/2014 2014-04-24 2014-01-01 2017-06-16T22:02:58Z 2017-06-16T22:02:58Z |
| dc.identifier.none.fl_str_mv | 10.1155/2014/924585 23146133 10.1155/2014/924585 http://dspace.utpl.edu.ec/handle/123456789/19110 |
| dc.language.none.fl_str_mv | Inglés |
| dc.publisher.none.fl_str_mv | BioMed Research International |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositorio Universidad Técnica Particular de Loja instname:Universidad Técnica Particular de Loja instacron:UTPL |
| dc.subject.none.fl_str_mv | berberine derivatives apoptosis autophagy colon cancer anticancer activity |
| dc.title.none.fl_str_mv | Multiple Effects of Berberine Derivatives on Colon Cancer Cells |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit this interesting feature, we synthesized three berberine derivatives, namely, NAX012, NAX014, and NAX018, and we tested their effects on two human colon carcinoma cell lines, that is, HCT116 and SW613-B3, which are characterized by wt and mutated p53, respectively. We observed that cell proliferation is more affected by cell treatment with the derivatives than with the lead compound; moreover, the derivatives proved to induce cell cycle arrest and cell death through apoptosis, thus suggesting that they could be promising anticancer drugs. Finally, we detected typical signs of autophagy in cells treated with berberine derivatives. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UTPL_04878ce53489a9d4a855ee6e3c0d52e4 |
| identifier_str_mv | 10.1155/2014/924585 23146133 |
| instacron_str | UTPL |
| institution | UTPL |
| instname_str | Universidad Técnica Particular de Loja |
| language_invalid_str_mv | Inglés |
| network_acronym_str | UTPL |
| network_name_str | Repositorio Universidad Técnica Particular de Loja |
| oai_identifier_str | oai:dspace.utpl.edu.ec:123456789/19110 |
| publishDate | 2014 |
| publisher.none.fl_str_mv | BioMed Research International |
| reponame_str | Repositorio Universidad Técnica Particular de Loja |
| repository.mail.fl_str_mv | . |
| repository.name.fl_str_mv | Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Loja |
| repository_id_str | 1227 |
| spelling | Multiple Effects of Berberine Derivatives on Colon Cancer CellsGuaman Ortiz, L.berberine derivativesapoptosisautophagycolon canceranticancer activityThe pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit this interesting feature, we synthesized three berberine derivatives, namely, NAX012, NAX014, and NAX018, and we tested their effects on two human colon carcinoma cell lines, that is, HCT116 and SW613-B3, which are characterized by wt and mutated p53, respectively. We observed that cell proliferation is more affected by cell treatment with the derivatives than with the lead compound; moreover, the derivatives proved to induce cell cycle arrest and cell death through apoptosis, thus suggesting that they could be promising anticancer drugs. Finally, we detected typical signs of autophagy in cells treated with berberine derivatives.BioMed Research International2017-06-16T22:02:58Z2014-04-242017-06-16T22:02:58Z2014-01-0118/06/2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10.1155/2014/9245852314613310.1155/2014/924585http://dspace.utpl.edu.ec/handle/123456789/19110Inglésinfo:eu-repo/semantics/openAccessreponame:Repositorio Universidad Técnica Particular de Lojainstname:Universidad Técnica Particular de Lojainstacron:UTPL2017-06-16T22:02:58Zoai:dspace.utpl.edu.ec:123456789/19110Institucionalhttps://dspace.utpl.edu.ec/Institución privadahttps://www.utpl.edu.ec/https://dspace.utpl.edu.ec/oai.Ecuador...opendoar:12272017-06-16T22:02:58Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Lojafalse |
| spellingShingle | Multiple Effects of Berberine Derivatives on Colon Cancer Cells Guaman Ortiz, L. berberine derivatives apoptosis autophagy colon cancer anticancer activity |
| status_str | publishedVersion |
| title | Multiple Effects of Berberine Derivatives on Colon Cancer Cells |
| title_full | Multiple Effects of Berberine Derivatives on Colon Cancer Cells |
| title_fullStr | Multiple Effects of Berberine Derivatives on Colon Cancer Cells |
| title_full_unstemmed | Multiple Effects of Berberine Derivatives on Colon Cancer Cells |
| title_short | Multiple Effects of Berberine Derivatives on Colon Cancer Cells |
| title_sort | Multiple Effects of Berberine Derivatives on Colon Cancer Cells |
| topic | berberine derivatives apoptosis autophagy colon cancer anticancer activity |
| url | http://dspace.utpl.edu.ec/handle/123456789/19110 |