Multiple Effects of Berberine Derivatives on Colon Cancer Cells

The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit this interesting feature, we synthesized three berberine derivatives, namely, NAX012, NAX014, and NAX...

Cur síos iomlán

Sábháilte in:
Sonraí bibleagrafaíochta
Príomhchruthaitheoir: Guaman Ortiz, L. (author)
Formáid: article
Foilsithe / Cruthaithe: 2014
Ábhair:
Rochtain ar líne:http://dspace.utpl.edu.ec/handle/123456789/19110
Clibeanna: Cuir clib leis
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
_version_ 1839346724071538688
author Guaman Ortiz, L.
author_facet Guaman Ortiz, L.
author_role author
collection Repositorio Universidad Técnica Particular de Loja
dc.creator.none.fl_str_mv Guaman Ortiz, L.
dc.date.none.fl_str_mv 18/06/2014
2014-04-24
2014-01-01
2017-06-16T22:02:58Z
2017-06-16T22:02:58Z
dc.identifier.none.fl_str_mv 10.1155/2014/924585
23146133
10.1155/2014/924585
http://dspace.utpl.edu.ec/handle/123456789/19110
dc.language.none.fl_str_mv Inglés
dc.publisher.none.fl_str_mv BioMed Research International
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.source.none.fl_str_mv reponame:Repositorio Universidad Técnica Particular de Loja
instname:Universidad Técnica Particular de Loja
instacron:UTPL
dc.subject.none.fl_str_mv berberine derivatives
apoptosis
autophagy
colon cancer
anticancer activity
dc.title.none.fl_str_mv Multiple Effects of Berberine Derivatives on Colon Cancer Cells
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
description The pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit this interesting feature, we synthesized three berberine derivatives, namely, NAX012, NAX014, and NAX018, and we tested their effects on two human colon carcinoma cell lines, that is, HCT116 and SW613-B3, which are characterized by wt and mutated p53, respectively. We observed that cell proliferation is more affected by cell treatment with the derivatives than with the lead compound; moreover, the derivatives proved to induce cell cycle arrest and cell death through apoptosis, thus suggesting that they could be promising anticancer drugs. Finally, we detected typical signs of autophagy in cells treated with berberine derivatives.
eu_rights_str_mv openAccess
format article
id UTPL_04878ce53489a9d4a855ee6e3c0d52e4
identifier_str_mv 10.1155/2014/924585
23146133
instacron_str UTPL
institution UTPL
instname_str Universidad Técnica Particular de Loja
language_invalid_str_mv Inglés
network_acronym_str UTPL
network_name_str Repositorio Universidad Técnica Particular de Loja
oai_identifier_str oai:dspace.utpl.edu.ec:123456789/19110
publishDate 2014
publisher.none.fl_str_mv BioMed Research International
reponame_str Repositorio Universidad Técnica Particular de Loja
repository.mail.fl_str_mv .
repository.name.fl_str_mv Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Loja
repository_id_str 1227
spelling Multiple Effects of Berberine Derivatives on Colon Cancer CellsGuaman Ortiz, L.berberine derivativesapoptosisautophagycolon canceranticancer activityThe pharmacological use of the plant alkaloid berberine is based on its antibacterial and anti-inflammatory properties; recently, anticancer activity has been attributed to this compound. To exploit this interesting feature, we synthesized three berberine derivatives, namely, NAX012, NAX014, and NAX018, and we tested their effects on two human colon carcinoma cell lines, that is, HCT116 and SW613-B3, which are characterized by wt and mutated p53, respectively. We observed that cell proliferation is more affected by cell treatment with the derivatives than with the lead compound; moreover, the derivatives proved to induce cell cycle arrest and cell death through apoptosis, thus suggesting that they could be promising anticancer drugs. Finally, we detected typical signs of autophagy in cells treated with berberine derivatives.BioMed Research International2017-06-16T22:02:58Z2014-04-242017-06-16T22:02:58Z2014-01-0118/06/2014info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10.1155/2014/9245852314613310.1155/2014/924585http://dspace.utpl.edu.ec/handle/123456789/19110Inglésinfo:eu-repo/semantics/openAccessreponame:Repositorio Universidad Técnica Particular de Lojainstname:Universidad Técnica Particular de Lojainstacron:UTPL2017-06-16T22:02:58Zoai:dspace.utpl.edu.ec:123456789/19110Institucionalhttps://dspace.utpl.edu.ec/Institución privadahttps://www.utpl.edu.ec/https://dspace.utpl.edu.ec/oai.Ecuador...opendoar:12272017-06-16T22:02:58Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Lojafalse
spellingShingle Multiple Effects of Berberine Derivatives on Colon Cancer Cells
Guaman Ortiz, L.
berberine derivatives
apoptosis
autophagy
colon cancer
anticancer activity
status_str publishedVersion
title Multiple Effects of Berberine Derivatives on Colon Cancer Cells
title_full Multiple Effects of Berberine Derivatives on Colon Cancer Cells
title_fullStr Multiple Effects of Berberine Derivatives on Colon Cancer Cells
title_full_unstemmed Multiple Effects of Berberine Derivatives on Colon Cancer Cells
title_short Multiple Effects of Berberine Derivatives on Colon Cancer Cells
title_sort Multiple Effects of Berberine Derivatives on Colon Cancer Cells
topic berberine derivatives
apoptosis
autophagy
colon cancer
anticancer activity
url http://dspace.utpl.edu.ec/handle/123456789/19110