Genotipificación del virus de papiloma humano por PCR tiempo real de muestras parafinadas de tejido cérvico uterino del año 2012, procedentes del hospital de Solca núcleo Loja
Cervical cancer is the second cause of mortality in Ecuadorian women by oncological diseases, according to INEC 2012 data. Persistent infection by certain genotypes of high oncogenic risk of human papillomavirus (HPV) is the main etiological factor for the development of this neoplasia. However, it...
Furkejuvvon:
| Váldodahkki: | |
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| Materiálatiipa: | bachelorThesis |
| Giella: | spa |
| Almmustuhtton: |
2014
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| Fáttát: | |
| Liŋkkat: | http://dspace.utpl.edu.ec/handle/123456789/10476 |
| Fáddágilkorat: |
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Lasit fáddágilkoriid | Čoahkkáigeassu: | Cervical cancer is the second cause of mortality in Ecuadorian women by oncological diseases, according to INEC 2012 data. Persistent infection by certain genotypes of high oncogenic risk of human papillomavirus (HPV) is the main etiological factor for the development of this neoplasia. However, it is known that the distribution of HPV types varies according to geographical location, which makes relevant the determination of the HPV types in our population. In this study we used real-time PCR to identify viral genotypes that were in 45 samples of cervical tissue previously fixed in paraffin with precancerous lesions (NIC I, NIC II, NIC III) and cancer in 2012, all of them were obtained from SOLCA-Loja. The results show the presence of the virus in 82% of the samples, and the most prevalent genotypes were: 16 and 18 with around 21%, 20% respectively. The data are consistent with studies conducted around the world that show that 16 and 18 genotypes are the most frequent in cervical cancer. |
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