Effect of new Berberine derivatives on colon cancer cells

The plant alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy, several derivatives have been designed and synthesized, and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, we i...

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Váldodahkki: Guaman Ortiz, L. (author)
Materiálatiipa: article
Almmustuhtton: 2015
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Liŋkkat:http://dspace.utpl.edu.ec/handle/123456789/19016
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author Guaman Ortiz, L.
author_facet Guaman Ortiz, L.
author_role author
collection Repositorio Universidad Técnica Particular de Loja
dc.creator.none.fl_str_mv Guaman Ortiz, L.
dc.date.none.fl_str_mv 2015-06-11
2015-01-01
2017-06-16T22:02:47Z
2017-06-16T22:02:47Z
dc.identifier.none.fl_str_mv 10.1093/abbs/gmv077
16729145
10.1093/abbs/gmv077
http://dspace.utpl.edu.ec/handle/123456789/19016
dc.language.none.fl_str_mv Inglés
dc.publisher.none.fl_str_mv Acta Biochimica et Biophysica Sinica
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.source.none.fl_str_mv reponame:Repositorio Universidad Técnica Particular de Loja
instname:Universidad Técnica Particular de Loja
instacron:UTPL
dc.subject.none.fl_str_mv apoptosis
autophagy
berberine
colon cancer
fluorescence
dc.title.none.fl_str_mv Effect of new Berberine derivatives on colon cancer cells
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/article
description The plant alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy, several derivatives have been designed and synthesized, and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, we identified five compounds able to heavily affect the proliferation of two human colon carcinoma cell lines, i.e. HCT116 and SW613-B3. Remarkably, the active compounds are characterized by high fluorescence emission property and ability to induce autophagy.
eu_rights_str_mv openAccess
format article
id UTPL_ec3feeed57f8d2d901f970bff81a74b1
identifier_str_mv 10.1093/abbs/gmv077
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instacron_str UTPL
institution UTPL
instname_str Universidad Técnica Particular de Loja
language_invalid_str_mv Inglés
network_acronym_str UTPL
network_name_str Repositorio Universidad Técnica Particular de Loja
oai_identifier_str oai:dspace.utpl.edu.ec:123456789/19016
publishDate 2015
publisher.none.fl_str_mv Acta Biochimica et Biophysica Sinica
reponame_str Repositorio Universidad Técnica Particular de Loja
repository.mail.fl_str_mv .
repository.name.fl_str_mv Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Loja
repository_id_str 1227
spelling Effect of new Berberine derivatives on colon cancer cellsGuaman Ortiz, L.apoptosisautophagyberberinecolon cancerfluorescenceThe plant alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy, several derivatives have been designed and synthesized, and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, we identified five compounds able to heavily affect the proliferation of two human colon carcinoma cell lines, i.e. HCT116 and SW613-B3. Remarkably, the active compounds are characterized by high fluorescence emission property and ability to induce autophagy.Acta Biochimica et Biophysica Sinica2017-06-16T22:02:47Z2015-06-112017-06-16T22:02:47Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10.1093/abbs/gmv0771672914510.1093/abbs/gmv077http://dspace.utpl.edu.ec/handle/123456789/19016Inglésinfo:eu-repo/semantics/openAccessreponame:Repositorio Universidad Técnica Particular de Lojainstname:Universidad Técnica Particular de Lojainstacron:UTPL2017-06-16T22:02:47Zoai:dspace.utpl.edu.ec:123456789/19016Institucionalhttps://dspace.utpl.edu.ec/Institución privadahttps://www.utpl.edu.ec/https://dspace.utpl.edu.ec/oai.Ecuador...opendoar:12272017-06-16T22:02:47Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Lojafalse
spellingShingle Effect of new Berberine derivatives on colon cancer cells
Guaman Ortiz, L.
apoptosis
autophagy
berberine
colon cancer
fluorescence
status_str publishedVersion
title Effect of new Berberine derivatives on colon cancer cells
title_full Effect of new Berberine derivatives on colon cancer cells
title_fullStr Effect of new Berberine derivatives on colon cancer cells
title_full_unstemmed Effect of new Berberine derivatives on colon cancer cells
title_short Effect of new Berberine derivatives on colon cancer cells
title_sort Effect of new Berberine derivatives on colon cancer cells
topic apoptosis
autophagy
berberine
colon cancer
fluorescence
url http://dspace.utpl.edu.ec/handle/123456789/19016