Effect of new Berberine derivatives on colon cancer cells
The plant alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy, several derivatives have been designed and synthesized, and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, we i...
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| Үндсэн зохиолч: | |
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| Формат: | article |
| Хэвлэсэн: |
2015
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| Нөхцлүүд: | |
| Онлайн хандалт: | http://dspace.utpl.edu.ec/handle/123456789/19016 |
| Шошгууд: |
Шошго нэмэх
Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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Шошго нэмэх | _version_ | 1839346723552493568 |
|---|---|
| author | Guaman Ortiz, L. |
| author_facet | Guaman Ortiz, L. |
| author_role | author |
| collection | Repositorio Universidad Técnica Particular de Loja |
| dc.creator.none.fl_str_mv | Guaman Ortiz, L. |
| dc.date.none.fl_str_mv | 2015-06-11 2015-01-01 2017-06-16T22:02:47Z 2017-06-16T22:02:47Z |
| dc.identifier.none.fl_str_mv | 10.1093/abbs/gmv077 16729145 10.1093/abbs/gmv077 http://dspace.utpl.edu.ec/handle/123456789/19016 |
| dc.language.none.fl_str_mv | Inglés |
| dc.publisher.none.fl_str_mv | Acta Biochimica et Biophysica Sinica |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositorio Universidad Técnica Particular de Loja instname:Universidad Técnica Particular de Loja instacron:UTPL |
| dc.subject.none.fl_str_mv | apoptosis autophagy berberine colon cancer fluorescence |
| dc.title.none.fl_str_mv | Effect of new Berberine derivatives on colon cancer cells |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | The plant alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy, several derivatives have been designed and synthesized, and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, we identified five compounds able to heavily affect the proliferation of two human colon carcinoma cell lines, i.e. HCT116 and SW613-B3. Remarkably, the active compounds are characterized by high fluorescence emission property and ability to induce autophagy. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UTPL_ec3feeed57f8d2d901f970bff81a74b1 |
| identifier_str_mv | 10.1093/abbs/gmv077 16729145 |
| instacron_str | UTPL |
| institution | UTPL |
| instname_str | Universidad Técnica Particular de Loja |
| language_invalid_str_mv | Inglés |
| network_acronym_str | UTPL |
| network_name_str | Repositorio Universidad Técnica Particular de Loja |
| oai_identifier_str | oai:dspace.utpl.edu.ec:123456789/19016 |
| publishDate | 2015 |
| publisher.none.fl_str_mv | Acta Biochimica et Biophysica Sinica |
| reponame_str | Repositorio Universidad Técnica Particular de Loja |
| repository.mail.fl_str_mv | . |
| repository.name.fl_str_mv | Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Loja |
| repository_id_str | 1227 |
| spelling | Effect of new Berberine derivatives on colon cancer cellsGuaman Ortiz, L.apoptosisautophagyberberinecolon cancerfluorescenceThe plant alkaloid berberine has been recently described as a promising anticancer drug. In order to improve its efficacy, several derivatives have been designed and synthesized, and found to be even more potent than the lead compound. Among the series of berberine derivatives we have produced, we identified five compounds able to heavily affect the proliferation of two human colon carcinoma cell lines, i.e. HCT116 and SW613-B3. Remarkably, the active compounds are characterized by high fluorescence emission property and ability to induce autophagy.Acta Biochimica et Biophysica Sinica2017-06-16T22:02:47Z2015-06-112017-06-16T22:02:47Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10.1093/abbs/gmv0771672914510.1093/abbs/gmv077http://dspace.utpl.edu.ec/handle/123456789/19016Inglésinfo:eu-repo/semantics/openAccessreponame:Repositorio Universidad Técnica Particular de Lojainstname:Universidad Técnica Particular de Lojainstacron:UTPL2017-06-16T22:02:47Zoai:dspace.utpl.edu.ec:123456789/19016Institucionalhttps://dspace.utpl.edu.ec/Institución privadahttps://www.utpl.edu.ec/https://dspace.utpl.edu.ec/oai.Ecuador...opendoar:12272017-06-16T22:02:47Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Lojafalse |
| spellingShingle | Effect of new Berberine derivatives on colon cancer cells Guaman Ortiz, L. apoptosis autophagy berberine colon cancer fluorescence |
| status_str | publishedVersion |
| title | Effect of new Berberine derivatives on colon cancer cells |
| title_full | Effect of new Berberine derivatives on colon cancer cells |
| title_fullStr | Effect of new Berberine derivatives on colon cancer cells |
| title_full_unstemmed | Effect of new Berberine derivatives on colon cancer cells |
| title_short | Effect of new Berberine derivatives on colon cancer cells |
| title_sort | Effect of new Berberine derivatives on colon cancer cells |
| topic | apoptosis autophagy berberine colon cancer fluorescence |
| url | http://dspace.utpl.edu.ec/handle/123456789/19016 |