Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The interaction between 13-phenylalkyl and 13-diphenylalkyl berberine derivatives (NAX) and human telomeric DNA G4 structures has been investigated by both spectroscopic and crystallographic methods. NAX042 and NAX053 are the best compounds impr...
Saved in:
| 主要作者: | |
|---|---|
| 格式: | article |
| 出版: |
2016
|
| 主题: | |
| 在线阅读: | http://dspace.utpl.edu.ec/handle/123456789/18865 |
| 标签: |
添加标签
没有标签, 成为第一个标记此记录!
|
添加标签 | _version_ | 1838705035781865472 |
|---|---|
| author | Guaman Ortiz, L. |
| author_facet | Guaman Ortiz, L. |
| author_role | author |
| collection | Repositorio Universidad Técnica Particular de Loja |
| dc.creator.none.fl_str_mv | Guaman Ortiz, L. |
| dc.date.none.fl_str_mv | 2016-01-01 2017-06-16T22:02:30Z 2017-06-16T22:02:30Z |
| dc.identifier.none.fl_str_mv | 10.1002/asia.201600116 18614728 10.1002/asia.201600116 http://dspace.utpl.edu.ec/handle/123456789/18865 |
| dc.publisher.none.fl_str_mv | Chemistry - An Asian Journal |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositorio Universidad Técnica Particular de Loja instname:Universidad Técnica Particular de Loja instacron:UTPL |
| dc.subject.none.fl_str_mv | Alkaloids Berberine Crystal structure G-quadruplexes Telomeric DNA X-ray diffraction |
| dc.title.none.fl_str_mv | Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/article |
| description | © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The interaction between 13-phenylalkyl and 13-diphenylalkyl berberine derivatives (NAX) and human telomeric DNA G4 structures has been investigated by both spectroscopic and crystallographic methods. NAX042 and NAX053 are the best compounds improving the performance of the natural precursor berberine. This finding is in agreement with the X-ray diffraction result for the NAX053-Tel12 adduct, showing the ligand which interacts via ?-stacking, sandwiched at the interface of two symmetry-related quadruplex units, with its benzhydryl group contributing to the overall stability of the adduct by means of additional ?-stacking interactions with the DNA residues. The berberine derivatives were also investigated for their cytotoxic activity towards a panel of human cancer cell lines. Compounds NAX042 and NAX053 affect the viability of cancer cell lines in a dose-dependent manner. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UTPL_f858c853d18ad3fcbbabccad92f44ef7 |
| identifier_str_mv | 10.1002/asia.201600116 18614728 |
| instacron_str | UTPL |
| institution | UTPL |
| instname_str | Universidad Técnica Particular de Loja |
| network_acronym_str | UTPL |
| network_name_str | Repositorio Universidad Técnica Particular de Loja |
| oai_identifier_str | oai:dspace.utpl.edu.ec:123456789/18865 |
| publishDate | 2016 |
| publisher.none.fl_str_mv | Chemistry - An Asian Journal |
| reponame_str | Repositorio Universidad Técnica Particular de Loja |
| repository.mail.fl_str_mv | . |
| repository.name.fl_str_mv | Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Loja |
| repository_id_str | 1227 |
| spelling | Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexesGuaman Ortiz, L.AlkaloidsBerberineCrystal structureG-quadruplexesTelomeric DNAX-ray diffraction© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The interaction between 13-phenylalkyl and 13-diphenylalkyl berberine derivatives (NAX) and human telomeric DNA G4 structures has been investigated by both spectroscopic and crystallographic methods. NAX042 and NAX053 are the best compounds improving the performance of the natural precursor berberine. This finding is in agreement with the X-ray diffraction result for the NAX053-Tel12 adduct, showing the ligand which interacts via ?-stacking, sandwiched at the interface of two symmetry-related quadruplex units, with its benzhydryl group contributing to the overall stability of the adduct by means of additional ?-stacking interactions with the DNA residues. The berberine derivatives were also investigated for their cytotoxic activity towards a panel of human cancer cell lines. Compounds NAX042 and NAX053 affect the viability of cancer cell lines in a dose-dependent manner.Chemistry - An Asian Journal2017-06-16T22:02:30Z2017-06-16T22:02:30Z2016-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10.1002/asia.2016001161861472810.1002/asia.201600116http://dspace.utpl.edu.ec/handle/123456789/18865info:eu-repo/semantics/openAccessreponame:Repositorio Universidad Técnica Particular de Lojainstname:Universidad Técnica Particular de Lojainstacron:UTPL2017-06-16T22:02:30Zoai:dspace.utpl.edu.ec:123456789/18865Institucionalhttps://dspace.utpl.edu.ec/Institución privadahttps://www.utpl.edu.ec/https://dspace.utpl.edu.ec/oai.Ecuador...opendoar:12272017-06-16T22:02:30Repositorio Universidad Técnica Particular de Loja - Universidad Técnica Particular de Lojafalse |
| spellingShingle | Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes Guaman Ortiz, L. Alkaloids Berberine Crystal structure G-quadruplexes Telomeric DNA X-ray diffraction |
| status_str | publishedVersion |
| title | Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes |
| title_full | Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes |
| title_fullStr | Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes |
| title_full_unstemmed | Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes |
| title_short | Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes |
| title_sort | Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes |
| topic | Alkaloids Berberine Crystal structure G-quadruplexes Telomeric DNA X-ray diffraction |
| url | http://dspace.utpl.edu.ec/handle/123456789/18865 |