Synthesis and characterization of nanostructured of TiO2 materials for controlled release of antiepileptic drugs

Advances science, and the future of technology is presented in new areas, such as the use of nanotechnology in the medical field, is increasingly relevant due to the great advantages that the application of this science provides. Epilepsy is neurological disorder characterized by abnormal electrical activity in the brain, which can result in partial or generalized seizures. The objective of treatment with antiepileptic drugs (AEDs) is to release the drug in sufficient quantities to reduce the frequency and severity of seizures. Some controlled release systems were developed with the objective to improve bioavailability and reducing the adverse effects present in conventional therapies. An alternative to administer AEDs in the brain are the nanoscale delivery systems, since due to their size (1-100 nm) they are ideal for both oral and parenteral administration. The aim of this work was the synthesis of nanostructured TiO2 materials by the sol-gel method, which allowed the incorporation of antiepileptic drugs with 1 % diphenylhydatoin (DPH) and 3% valproic acid (VPA) respectively, to get controlled release systems. The characterization of the synthesized nanostructures was carried out using the techniques of FTIR, UV-Vis DRS, XRD, BET and TEM. The in vitro release kinetics of the nanostructures contained with DPH were evaluated and adjusted to different mathematical models. The kinetics of in vitro release of the material loaded with DPH showed an adjustment to the Korsmeyer-Peppas model, indicative a Fickian diffusion release phenomenon.

• Hoofdauteur: Proaño Reyes, Cristian Eduardo (author)
• Formaat: bachelorThesis
• Taal: eng
• Gepubliceerd in: 2019
• Onderwerpen: Titania; Nanopartículas; Fármacos antiepilépticos; Liberación controlada; Nanoparticles; Antiepileptic drugs; Controlled release
• Online toegang: http://repositorio.yachaytech.edu.ec/handle/123456789/45