PEDOT-based microstructures for electrochemical loading and delivery of a neutral drug

Chronic pain leads to significant physical, emotional, social, and economic burdens, affecting over 20% of the global populartion. Traditional oral non-steroidal anti-inflammatory drug (NSAIDs), like ibuprofen, present bioavailability challenges and side effects; hence, innovative drug delivery systems are required. This study focuses on the development of electro-responsive microstructures based on poly(3,4-thylenedioxythiophene) (PEDOT) for controlled delivery of neutral ibuprofen (IBU) via electrical stimulation. The IBU loading into PEDOT films (PIBU) was evaluated using three methods: adsorption (AD), cyclic voltammetry after electropolymerization (CV), and cyclic voltammetry during electropolymerization (EP), which offered the highest release efficiency. Similarly, PIBU-EP-coated polyvinyl alcohol nanofibers (PVA-NF) microstructures (PIBU-EP-NF) were developed over indium tin oxide (ITO) electrodes via electrospinning and electropolymerization. The integration with PVA-NF significantly improved the mechanical stability and release efficiency of the material, demonstrating its potential in transdermal drug delivery applications. Its thermal and electrochemical stability, along with its high hydrophilicity, further support its promise. This work presents PIBU-EP-NF as a promising candidate for advanced drug delivery systems, offering the potential to reduce side effects, minimize environmental impact, and effectively manage pain.

• Autor principal: Cóndor Arboleda, Diana Katherine (author)
• Formato: bachelorThesis
• Idioma: eng
• Publicado em: 2024
• Assuntos: Liberación de fármacos; Microestructuras electro-responsivas; Estabilidad; Drug delivery; Electro-responsive microstructures; Stability
• Acesso em linha: http://repositorio.yachaytech.edu.ec/handle/123456789/845