Synthesis and characterization of ZnO nanoparticles as potential drug-controlled delivery carriers

This review examines the synthesis and characterization of zinc oxide nanoparticles (ZnO-NPs), particularly as potential carriers for controlled drug release. Due to their nanoscale size, surface-to-volume ratio, biocompatibility, and ease of functionalization, ZnO nanoparticles hold great potential for drug delivery applications (DDa). To get a clear picture of the current research, databases like SciFinder, Scopus, and Google Scholar were used, focusing on studies from the last four years (2020-2024). The search specifically looked at work on the synthesis, characterization, and application of ZnO nanoparticles (ZnO-NPs) for controlled drug release. Recent studies show that multiple synthesis approaches have been explored, ranging from traditional chemical methods to more sustainable green chemistry techniques. This reflects the growing interest in developing efficient and eco-friendly ways to produce ZnO-NPs for drug delivery. From a structural perspective, techniques such as XRD, SEM, TEM, FTIR, and UV-Vis spectroscopy have been widely used for the thorough characterization of ZnO-NPs. ZnO-NPs have also been employed for drug loading and controlled release, demonstrating their potential as therapeutic agents capable of enhancing drug stability or prolonging release profiles, thereby improving efficacy and reducing drug side effects. The analysis of the reported literature allowed for the identification of key factors for an efficient drug release profile, highlighting nanoparticle size and the ZnO-NP–drug interaction as fundamental considerations. In conclusion, ZnO-NPs are solid materials with a promising future. In recent years, their design and synthetic procedures have been developed and improved, specifically focusing on their application as controlled drug release systems, with the aim of developing new therapeutic treatments.

• المؤلف الرئيسي: Buele Ramírez, Georgi Alexander (author)
• التنسيق: bachelorThesis
• اللغة: eng
• منشور في: 2025
• الموضوعات: Nanopartículas de óxido de zinc; Administración de fármacos; Síntesis verde; Zinc oxide nanoparticles; Drug delivery; Green synthesis
• الوصول للمادة أونلاين: http://repositorio.yachaytech.edu.ec/handle/123456789/956