Factors influencing the differentiation of embryonic stem cells in cancer cells

Nowadays, Stem cells are a well-known topic, mainly because of their significant advantages and discoveries. Especially in embryonic stem cells, even though this type of stem cell brings several ethical problems, these are the most versatile in several fields. These cells are known for their self-renewal and proliferation properties; however, these two characteristics are also common in cancer cells. Stem cells have a relatively long lifetime than normal cells, making them suitable for genetic mutations. Moreover, when there are mutations, even if these mutations are small, stem cells may lose control of their growth or their characteristics mentioned above, such as self-renewal and proliferation, which most likely leads them to become cancer cells. The origin of cancer stem cells (CSCs) is still unknown, but several hypotheses suggest that these CSCs are the leading promoters of cancer metastases. This derivation in cancer stem cells may be due to several factors such as mutations mentioned above, genomic instability, and microenvironment, which will be mentioned throughout this work. Besides, we will study these cells' main characteristics: self-renewal and proliferation as two factors that influence CSCs on a large scale. This, to focus on improving processes that use stem cells as the primary source for further advances.

• Main Author: Cevallos Chicaiza, Josselyn Alejandra (author)
• Format: bachelorThesis
• Language: eng
• Published: 2021
• Subjects: Células madre; Cáncer; Auto-renovación; Microambiente; Stem cell; Cancer; Self-renewal; Microenvironment
• Online Access: http://repositorio.yachaytech.edu.ec/handle/123456789/344