Synthesis and Magnetic Properties of cobalt and nickel Complexes of perezone and related ligands
Perezone is a natural sesquiterpene benzoquinone useful to study oxidation-reduction systems. This compound is found in the roots of the Perezia genus, among which is the Perezia multiflora species. In Ecuador, Perezia multiflora is a medicinal plant known as "escorzonera". The cyt...
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| Format: | bachelorThesis |
| Idioma: | eng |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | http://repositorio.yachaytech.edu.ec/handle/123456789/170 |
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Afegir etiqueta | Sumari: | Perezone is a natural sesquiterpene benzoquinone useful to study oxidation-reduction systems. This compound is found in the roots of the Perezia genus, among which is the Perezia multiflora species. In Ecuador, Perezia multiflora is a medicinal plant known as "escorzonera". The cytotoxic effect of perezone has been evaluated against several cancer cells. As metals modify the properties of several drugs, transition metal complexes containing quinone ligands have been used in anticancer drugs and against other diseases. The binding ability of perezone to metals and its capacity to experience oxidation-reduction reactions allows playing an essential activity in the biological systems. In this work, through TLC, UV-Vis is observed the characteristic band for perezone and UPLC-MS analysis was found the presence of perezone in Perezia multiflora species. The redox properties of this quinones was also confirmed through the use of Potentiostat. Subsequently, the synthesis of Cobalt and Nickel complexes with perezone was carry on and characterized through UV-VIS spectroscopy. The results obtained showed that Nickel-Perezone complex has a coordination 1:2, while Cobalt-Perezone complex showed a coordination 1:1. On the other hand, EPR spectroscopy on those compounds showed hyperfine interaction for Nickel- Perezone complex although Nickel complexes are characterized for being EPR silent. Furthermore, an interesting characteristic on the EPR spectra obtained from the Cobalt-Perezone complex, there is a lack of hyperfine coupling. The magnetic studies carry on those complexes showed an antiferromagnetic behavior and their Neel temperatures very low TN= 1,79 for Cobalt-Perezone and for Nickel Perezone a TN=1,99. From the analysis, also was obtained small values for Weiss constant indicating low transition temperature between paramagnetic and antiferromagnetic behavior. |
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