Development and characterization of a novel nanobiomaterial: PVA/Gelatine/ Silver nanoparticles functionalized with propolis for biomedical applications
In this work, we developed a polyvinyl alcohol (PVA) nanocomposite reinforced with graphene oxide (GO) and silver nanoparticles (Ag-NP) with antibacterial properties against E. Coli and S. Aureus. The dispersion of Ag-NP and GO in the PVA matrix was optimized using gelatin (Gt) as a natural dispersa...
שמור ב:
| מחבר ראשי: | |
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| פורמט: | bachelorThesis |
| שפה: | eng |
| יצא לאור: |
2025
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| נושאים: | |
| גישה מקוונת: | http://repositorio.yachaytech.edu.ec/handle/123456789/922 |
| תגים: |
הוספת תג
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הוספת תג | סיכום: | In this work, we developed a polyvinyl alcohol (PVA) nanocomposite reinforced with graphene oxide (GO) and silver nanoparticles (Ag-NP) with antibacterial properties against E. Coli and S. Aureus. The dispersion of Ag-NP and GO in the PVA matrix was optimized using gelatin (Gt) as a natural dispersant. PVA/Gt, PVA/Gt/GO, PVA/Gt/Ag-Np, PVA/Gt/Ag-Np and PVA/Gt/GO/Ag-Np nanocomposites were synthesized and characterized by casting and freeze/thaw crosslinking techniques. Compositions of PVA/Gt at ratios of 100:0, 90:10, 80:20 and 70:30, with the addition of 0% and 0.05% GO, and 2mL and 4mL Ag-Np were studied. The results showed that the chemical and crystalline structure of PVA did not change with the addition of Gt or nanofillers, although the secondary interactions between PVA and Gt altered its thermal and mechanical properties. The highest thermal stability was achieved with the addition of 10% Gt and 0.05% GO, increasing the decomposition temperature from 330°C to 349°C. The addition of GO improved the mechanical properties of the material, increasing the tensile strength and Young's modulus by 107.85%, although it decreased the elongation by 98.14%. In the antimicrobial tests, the materials with Ag-Np inhibited the growth of E. Coli and S. Aureus, being more effective the inhibition in those with greater volume of nanoparticles (4mL). In addition, the presence of GO, due to its nanostructure, enhanced the antibacterial capacity of Ag-Np in the biocomposites, improving the distribution of both nanoparticles within the material. This study demonstrates the potential of the developed nanocomposites for applications in medical biomaterials, such as wound dressings or antibacterial coatings. |
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