Phytochemical study and biological activities of Ecuadorian plants traditionally used in the treatment of skin diseases
In Ecuador, a megadiverse country, new plant species are discovered every year. This makes it impossible to study many of them, particularly in relation to their secondary metabolites that may be of medical therapeutic interest, as an alternative to synthetic drugs. This thesis studies the phytochem...
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| 格式: | bachelorThesis |
| 語言: | eng |
| 出版: |
2022
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| 主題: | |
| 在線閱讀: | http://repositorio.yachaytech.edu.ec/handle/123456789/572 |
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添加標簽 | 總結: | In Ecuador, a megadiverse country, new plant species are discovered every year. This makes it impossible to study many of them, particularly in relation to their secondary metabolites that may be of medical therapeutic interest, as an alternative to synthetic drugs. This thesis studies the phytochemistry and bioactivity of four native plant species from Ecuador based on methanolic extracts: Juglans neotropica, Duranta triacantha, Mikania sp. and Brugmansia aurea. First, a qualitative phytochemical screening was performed to detect phenols, alkaloids and terpenes, as well as their derivatives. Second, for the species with the highest number of positive results in the qualitative tests, the flavonoid and phenol contents were quantified. In addition, antibacterial and antifungal bioactivity tests were performed for the four species. Among the four species, J. neotropica had the highest extraction yield and the highest presence of secondary metabolites, with the exception of cardiac glycosides and coumarins. Regarding the quantification of flavonoids and phenols of this species, 244.8 mg QE/g extract and 225.8 mg GAE/g extract, respectively, were measured. In addition, it was found to present moderate bioactive against bacterial strains of Enterococcus faecalis, Staphylococcus aureus, Listeria monocytogenes, Escherichia coli and Pseudomonas aeruginosa, as well as against the fungal strain Candida albicans. On the other hand, D. triacantha was positive for most secondary metabolites tested, although neither phenols nor alkaloids were detected. This species also showed antibacterial and antifungal activity, but only against Listeria monocytogenes and Aspergillus niger, respectively. The methanolic extracts of Mikania sp. and B. aurea had secondary metabolites in common, such as phenols, tannins and saponins, but only Mikania sp. had antibacterial bioactivity against Staphylococcus aureus and Listeria monocytogenes and antifungal bioactivity against Aspergillus niger. In conclusion, all the species studied could have potential medical applications. J. neotropica, having many secondary metabolites and high antibacterial and antifungal activity, could be used to treat skin diseases. D. triacantha possesses an interesting variety of secondary metabolites, so more studies can be done on this area, while Mikania sp. and B. aurea, which presented only a few secondary metabolites, could be the object of hydrogel development because of the mucilage they apparently exhibit. |
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