Chitosan/Lignin biopolymer doped samarium for potential use in drug delivery
Polymeric nanoparticle-based drug carriers represent a wonderful avenue for cancer therapy. In this work, we study the use of chitosan and lignin doped with Sm nanoparticles to create polymeric systems with the aim of studying their potential use as carriers of the anticancer drug, curcumin. Sm nano...
שמור ב:
| מחבר ראשי: | |
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| פורמט: | bachelorThesis |
| שפה: | eng |
| יצא לאור: |
2024
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| נושאים: | |
| גישה מקוונת: | http://repositorio.yachaytech.edu.ec/handle/123456789/735 |
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הוספת תג
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הוספת תג | _version_ | 1863534792513945600 |
|---|---|
| author | Quezada Correa, Gilda Cecibel |
| author_facet | Quezada Correa, Gilda Cecibel |
| author_role | author |
| collection | Repositorio Universidad Yachay Tech |
| dc.contributor.none.fl_str_mv | González Vázquez, Gema López González, Floralba Aggeny |
| dc.creator.none.fl_str_mv | Quezada Correa, Gilda Cecibel |
| dc.date.none.fl_str_mv | 2024-04-01T15:55:43Z 2024-04-01T15:55:43Z 2024-03 |
| dc.identifier.none.fl_str_mv | http://repositorio.yachaytech.edu.ec/handle/123456789/735 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Universidad de Investigación de Tecnología Experimental Yachay |
| dc.rights.none.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositorio Universidad Yachay Tech instname:Universidad Yachay Tech instacron:Yachay |
| dc.subject.none.fl_str_mv | Quitosano Lignina Nanopartículas de Samario Chitosan Lignin Samarium nanoparticles |
| dc.title.none.fl_str_mv | Chitosan/Lignin biopolymer doped samarium for potential use in drug delivery |
| dc.type.none.fl_str_mv | info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/bachelorThesis |
| description | Polymeric nanoparticle-based drug carriers represent a wonderful avenue for cancer therapy. In this work, we study the use of chitosan and lignin doped with Sm nanoparticles to create polymeric systems with the aim of studying their potential use as carriers of the anticancer drug, curcumin. Sm nanoparticles were synthesized by hydrothermal and precipitation methods, and characterized by XRD and TEM to observe their rod-shaped morphology. Electrostatic coassembly facilitated the formation of Chi/Lig core–shell particles, which was confirmed by SEM and EDX analysis. FTIR characterization suggested interactions between chitosan, lignin, and Sm, indicating possible hydrogen bonding and coordinate bond formation. UV-Vis spectroscopy and fluorescence microscopy confirmed the presence of Sm NPs and revealed a higher intensity at 50 ppm. Finally, we studied the encapsulation and release of curcumin in five polymeric systems: Lig-Cur, Chi/Lig-Cur, Chi/Lig/Sm-Cur, Chi-Cur, and Chi/Sm-Cur. Drug release using the polymeric systems was followed by UV-Vis spectroscopy for 28 hours, in both simulated gastric fluid (pH 3) and simulated intestinal fluid (pH 7). The presence of lignin in the polymeric systems contributed to a slower release of curcumin (less than 49%) compared to systems with pure chitosan (more than 67%), which is a favorable characteristic for their application as pH-sensitive drug carriers. |
| eu_rights_str_mv | openAccess |
| format | bachelorThesis |
| id | Yachay_cd5af783c2c6d6d30b4f2ec93018e46f |
| instacron_str | Yachay |
| institution | Yachay |
| instname_str | Universidad Yachay Tech |
| language | eng |
| network_acronym_str | Yachay |
| network_name_str | Repositorio Universidad Yachay Tech |
| oai_identifier_str | oai:repositorio.yachaytech.edu.ec:123456789/735 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Universidad de Investigación de Tecnología Experimental Yachay |
| reponame_str | Repositorio Universidad Yachay Tech |
| repository.mail.fl_str_mv | . |
| repository.name.fl_str_mv | Repositorio Universidad Yachay Tech - Universidad Yachay Tech |
| repository_id_str | 10284 |
| spelling | Chitosan/Lignin biopolymer doped samarium for potential use in drug deliveryQuezada Correa, Gilda CecibelQuitosanoLigninaNanopartículas de SamarioChitosanLigninSamarium nanoparticlesPolymeric nanoparticle-based drug carriers represent a wonderful avenue for cancer therapy. In this work, we study the use of chitosan and lignin doped with Sm nanoparticles to create polymeric systems with the aim of studying their potential use as carriers of the anticancer drug, curcumin. Sm nanoparticles were synthesized by hydrothermal and precipitation methods, and characterized by XRD and TEM to observe their rod-shaped morphology. Electrostatic coassembly facilitated the formation of Chi/Lig core–shell particles, which was confirmed by SEM and EDX analysis. FTIR characterization suggested interactions between chitosan, lignin, and Sm, indicating possible hydrogen bonding and coordinate bond formation. UV-Vis spectroscopy and fluorescence microscopy confirmed the presence of Sm NPs and revealed a higher intensity at 50 ppm. Finally, we studied the encapsulation and release of curcumin in five polymeric systems: Lig-Cur, Chi/Lig-Cur, Chi/Lig/Sm-Cur, Chi-Cur, and Chi/Sm-Cur. Drug release using the polymeric systems was followed by UV-Vis spectroscopy for 28 hours, in both simulated gastric fluid (pH 3) and simulated intestinal fluid (pH 7). The presence of lignin in the polymeric systems contributed to a slower release of curcumin (less than 49%) compared to systems with pure chitosan (more than 67%), which is a favorable characteristic for their application as pH-sensitive drug carriers.Los portadores de fármacos basados en nanopartículas poliméricas representan una vía maravillosa para la terapia contra el cáncer. En este trabajo, estudiamos el uso de quitosano y lignina dopados con nanopartículas de Sm para crear sistemas polimericos con el objetivo de estudiar su potencial uso como portadores del fármaco anticancerígeno, curcumina. Las nanoparticulas de Sm se sintetizaron mediante métodos hidrotermales y de precipitación, y se caracterizaron mediante XRD y TEM para observar su morfología en forma de varilla. El coensamblaje electrostático facilitó la formación de partículas núcleo-cubierta de Chi/Lig, lo cual fue confirmado mediante análisis SEM y EDX. La caracterización FTIR sugirió interacciones entre quitosano, lignina y Sm, lo que indica posibles enlaces de hidrógeno y formación de enlaces coordinados. La espectroscopía UV-Vis y microscopia de fluorescencia confirmaron la presencia de NPs de Sm y revelaron una mayor intensidad a 50 ppm. Finalmente, estudiamos la encapsulación y liberación de la curcumina en cinco sistemas poliméricos: Lig-Cur, Chi/Lig-Cur, Chi/Lig/Sm-Cur, Chi-Cur y Chi/Sm-Cur. La liberación del fármaco usando los sistemas poliméricos se siguio mediante espectroscopía UV-Vis durante 28 horas, tanto en fluido gástrico simulado (pH 3) como en fluido intestinal simulado (pH 7). La presencia de lignina en los sistemas poliméricos contribuyó a una liberación más lenta de curcumina (menos del 49%) en comparación con los sistemas con quitosano puro (más del 67%), lo que es una característica favorable para su aplicación como portadores de fármacos anticancerígenos sensibles al pH.Ingeniero/a en NanotecnologíaUniversidad de Investigación de Tecnología Experimental YachayGonzález Vázquez, GemaLópez González, Floralba Aggeny2024-04-01T15:55:43Z2024-04-01T15:55:43Z2024-03info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesishttp://repositorio.yachaytech.edu.ec/handle/123456789/735enginfo:eu-repo/semantics/openAccessreponame:Repositorio Universidad Yachay Techinstname:Universidad Yachay Techinstacron:Yachay2024-04-02T15:13:27Zoai:repositorio.yachaytech.edu.ec:123456789/735Institucionalhttps://repositorio.yachaytech.edu.ec/Universidad públicahttps://www.yachaytech.edu.ec/https://repositorio.yachaytech.edu.ec/oaiEcuador...opendoar:102842024-04-02T15:13:27falseInstitucionalhttps://repositorio.yachaytech.edu.ec/Universidad públicahttps://www.yachaytech.edu.ec/https://repositorio.yachaytech.edu.ec/oai.Ecuador...opendoar:102842024-04-02T15:13:27Repositorio Universidad Yachay Tech - Universidad Yachay Techfalse |
| spellingShingle | Chitosan/Lignin biopolymer doped samarium for potential use in drug delivery Quezada Correa, Gilda Cecibel Quitosano Lignina Nanopartículas de Samario Chitosan Lignin Samarium nanoparticles |
| status_str | publishedVersion |
| title | Chitosan/Lignin biopolymer doped samarium for potential use in drug delivery |
| title_full | Chitosan/Lignin biopolymer doped samarium for potential use in drug delivery |
| title_fullStr | Chitosan/Lignin biopolymer doped samarium for potential use in drug delivery |
| title_full_unstemmed | Chitosan/Lignin biopolymer doped samarium for potential use in drug delivery |
| title_short | Chitosan/Lignin biopolymer doped samarium for potential use in drug delivery |
| title_sort | Chitosan/Lignin biopolymer doped samarium for potential use in drug delivery |
| topic | Quitosano Lignina Nanopartículas de Samario Chitosan Lignin Samarium nanoparticles |
| url | http://repositorio.yachaytech.edu.ec/handle/123456789/735 |