Synthesis and characterization of cellulose-based hydrogels for antibiotic delivery against Leishmaniasis
Leishmaniasis is a neglected disease caused by protozoa of the genus Leishmania. It presents three main forms, visceral, cutaneous and mucocutaneous leishmaniasis. Cutaneous leishmaniasis is a public health problem in Ecuador because of its wide distribution, mainly in rural areas in the regions of...
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| Format: | bachelorThesis |
| Langue: | eng |
| Publié: |
2020
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| Accès en ligne: | http://repositorio.yachaytech.edu.ec/handle/123456789/131 |
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Ajouter un tag | Résumé: | Leishmaniasis is a neglected disease caused by protozoa of the genus Leishmania. It presents three main forms, visceral, cutaneous and mucocutaneous leishmaniasis. Cutaneous leishmaniasis is a public health problem in Ecuador because of its wide distribution, mainly in rural areas in the regions of Coast, Highlands, and Amazon. It can be found in 23 out of the 24 provinces. The first-line treatment is antimonate meglumine, and it has a large number of adverse effects in the patient and it can cause death. In addition, the cost of treatment is high, and it is developing resistance. Due to this, new alternatives are being sought, such as fluoroquinolones, which have been reported active on topoisomerases II of Leishmania spp.; it has lower cost and fewer adverse effects. On the other hand, hydrogels based on natural polysaccharide polymers, such as cellulose, are of great interest in biomedical applications, more specifically, for tissue regeneration and drug delivery. The aim of this work is to develop cellulose-based hydrogels that are loaded with enrofloxacin to have anti-leishmanial activity against promastigotes of Leishmania mexicana. Hydrogels are prepared using dissolving methods with the load of the antibiotic during the manufacturing process to avoid the loss of the active compound. The release profile and transdermal permeability were studied using the diffusion Franz Cell. Finally, these hydrogels have presented great results in the antibiotic release process in acid pH to be used in cutaneous wounds of Leishmaniasis. In addition, they present a high level of anti-leishmanial activity. The obtained data encouraged the use of these hydrogels for cutaneous leishmaniasis wound healing. |
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