Production of polytetrafluoroethylene nanoparticles: towards the design of bio-functional nanoparticles

Fascinating properties shown bypolytetrafluoroethylene (PTFE)have attracted the attention of scientists as this material has found several applications in the biomedical field. Some studies have highlighted the potential ofPTFEinultrasound (US)attenuation. The present work aims at synthesizing PTFE nanoparticles (NPs)and characterizing them as new nanoplatforms for the hyperthermia treatment of cancer. ThesePTFENPswere obtained by dispersing Teflon sealant in a mixture ofhydrofluoric acid (HF) and ethanol, followed by sonication and differential centrifugation before being stabilized inpolysorbate 80 (Tween-80). This yielded bimodal population ofPTFENPsof 14 nm and 105 nm in average size as displayed byTransmission Electron Microscopy (TEM)images. Additionally,Fourier-Transform Infrared spectroscopy (FTIR),X-ray diffraction (XRD)and diffuse reflectanceultraviolet visible spectroscopy (UV- Vis)were used to further characterize the as-produced PTFE NPs. For instance,XRDdisplays peaks due to the presence ofPTFENPsin addition to peaks from contamination with rutile. Moreover, thePTFE NPshave shown their potential in X-ray andUSimaging. Ultimately, the outlook of PTFE in the medical field is presented for cancer theranostics.

• Príomhchruthaitheoir: Chingo Aimacaña, Cristhian Marcelo (author)
• Formáid: bachelorThesis
• Teanga: eng
• Foilsithe / Cruthaithe: 2019
• Ábhair: PTFE NPs; Synthesis; Colloidal Stability; Characterization; Biomedical Properties; Imag- ing; Theranostics; NPs de PTFE; Síntesis; Estabilidad Coloidal; Caracterización; Propiedades Biomédi- cas; Imágenes; Teragnosis
• Rochtain ar líne: http://repositorio.yachaytech.edu.ec/handle/123456789/81