Multifunctional drug delivery system based on La-Hydroxyapatite/Fe3O4/Chitosan

Hydroxyapatite and chitosan composites are widely explored as biocompatible carriers for controlled drug delivery; nevertheless, due to multifunctionality limits, new biomedical applications have caught the attention. Recent e!orts have focused on the development of multifunctional systems that incorporate both magnetic and luminescent components to enhance targeted delivery and imaging capabilities. For this reason, this research focuses on the synthesis of a doxorubicin-controlled release system based on La-HAp/Fe3O4/Cs pellets. The main objective is to study how the incorporation of additional functional components into the HAp/CS-based nanocomposites a!ects the drug release mechanism. The characterization techniques that allowed to understand the behavior of the system include: Fourier transform infrared spectroscopy (FTIR) for the analysis of chemical bonds, Raman spectroscopy for the analysis of molecular vibrations, scanning electron microscopy (SEM) for the study of the morphology of the di!usion system, energy dispersive X-ray spectroscopy (EDX) for elemental analysis, fluorescence microscopy and ultraviolet-visible spectroscopy (UV-Vis) for optical analysis of luminescence, absorption and release. The research allowed to determine that the most complex structure La-HAp/Fe3O4(in situ)/Cs was the one that presented the best sustained release capacity due to its porosity with 95.53% release after 75 hours, which denotes that in addition to the materials that are added to the matrix, the synthesis method also has a significant influence.

• Autor principal: Macas Ortega, Luis Fernando (author)
• Formato: bachelorThesis
• Publicado em: 2026
• Assuntos: Hidroxiapatita; Lantano; Magnetita; Hydroxyapatite; Lanthanum; Magnetite
• Acesso em linha: https://repositorio.yachaytech.edu.ec/handle/123456789/1048