Lessons from a Single Amino Acid Substitution: Anticancerand Antibacterial Properties of Two PhospholipaseA2-Derived Peptides

The membrane-active nature of phospholipase A2-derived peptides makes them potentialcandidates for antineoplastic and antibacterial therapies. Two short 13-mer C-terminal fragmentstaken from snake venom Lys49-PLA2toxins (p-AppK and p-Acl), differing by a leucine/phenylalaninesubstitution, were synth...

• 1. Verfasser: de Almeida, José R. (author)
• Weitere Verfasser: Mendes, Bruno (author), Lancellotti, Marcelo (author), Franchi, Gilberto C. Jr. (author), Passos, Óscar (author), Ramos, Maria J. (author), Fernandes, Pedro A. (author), Alves, Cláudia (author), Vale, Nuno (author), Gomes, Paula (author), da Silva, Saulo L. (author)
• Format: article
• Veröffentlicht: 2021
• Schlagworte: Agkistrodon; Leucine; Phenylalanine; Membrane; Venom peptides
• Online Zugang: https://doi.org/10.3390/cimb44010004A; http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/483