Lessons from a Single Amino Acid Substitution: Anticancerand Antibacterial Properties of Two PhospholipaseA2-Derived Peptides

Lessons from a Single Amino Acid Substitution: Anticancerand Antibacterial Properties of Two PhospholipaseA2-Derived Peptides

The membrane-active nature of phospholipase A2-derived peptides makes them potentialcandidates for antineoplastic and antibacterial therapies. Two short 13-mer C-terminal fragmentstaken from snake venom Lys49-PLA2toxins (p-AppK and p-Acl), differing by a leucine/phenylalaninesubstitution, were synth...

Description complète

Enregistré dans:

Détails bibliographiques
Auteur principal:	de Almeida, José R. (author)
Autres auteurs:	Mendes, Bruno (author), Lancellotti, Marcelo (author), Franchi, Gilberto C. Jr. (author), Passos, Óscar (author), Ramos, Maria J. (author), Fernandes, Pedro A. (author), Alves, Cláudia (author), Vale, Nuno (author), Gomes, Paula (author), da Silva, Saulo L. (author)
Format:	article
Publié:	2021
Sujets:	Agkistrodon Leucine; Phenylalanine Membrane; Venom peptides
Accès en ligne:	https://doi.org/10.3390/cimb44010004A http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/483
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Corrigendum to “Exploring and understanding the functional role, and biochemical and structural characteristics of an acidic phospholipase A2, AplTx-I, purified from Agkistrodon piscivorus leucostoma snake venom” [Toxicon 127 (2017) 22–36]
par: Resende, Leticia M.
Publié: (2017)

A novel synthetic peptide inspired on Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom active against multidrug-resistant clinical isolates
par: de Almeida, José R.
Publié: (2018)

Potential use of 13-mer peptides based on phospholipase and oligoarginine as leishmanicidal agents
par: Mendes, Bruno
Publié: (2019)

Harnessing snake venom phospholipases A2 to novel approaches for overcoming antibiotic resistance
par: de Almeida, José R.
Publié: (2018)

Dissection of phospholipases A2 reveals multifaceted peptides targeting cancer cells, Leishmania and bacteria
par: Peña Carrillo, María Sol
Publié: (2021)

Péptidos de veneno animal y venenos
par: Novo de Oliveira, Ana
Publié: (2023)

Antibacterial and Antiviral Properties of Chenopodin-Derived Synthetic Peptides
par: Espinosa de los Monteros Silva, Nina
Publié: (2024)

Globular polymer supports assisted scaled-up Membrane Enhanced Peptide Synthesis: an overview
par: Galeas Albán, Dayana Marleyn
Publié: (2024)

Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
par: de Almeida, José R.
Publié: (2023)

Anti-platelet aggregation activity of two novel acidic Asp49-phospholipases A2 from Bothrops brazili snake venom
par: Sobrinho, Juliana C.
Publié: (2018)

The synthesis of an EDTA-like chelating peptidomimetic building block suitable for solid-phase peptide synthesis
par: Spengler, Jan
Publié: (2017)

Phage display peptides: peptides mimicking natural epitopes
par: Guanoliquin Loachamin, Lady Vanessa
Publié: (2022)

Microscopic and metabolomics analysis of the anti-Listeria activity of natural and engineered cruzioseptins
par: Bermúdez Puga, Sebastián
Publié: (2024)

Traditional and Computational Screening of Non-Toxic Peptides and Approaches to Improving Selectivity
par: Robles Loaiza, Alberto A.
Publié: (2022)

Peptides to Tackle Leishmaniasis: Current Status and Future Directions
par: Robles Loaiza, Alberto Alejandro
Publié: (2021)

Cruzioseptins, antibacterial peptides from Cruziohyla calcarifer skin, as promising leishmanicidal agents
par: Mendes, Bruno
Publié: (2020)

Isolation, structural and functional characterization of a new Lys49 phospholipase A2 homologue from Bothrops neuwiedi urutu with bactericidal potential
par: Correa, Edailson A.
Publié: (2016)

Molecular modeling of four Dermaseptin-related peptides of the gliding tree frog Agalychnis spurrelli
par: Cuesta, Sebastian
Publié: (2019)

Picturins and Pictuseptins, two novel antimicrobial peptide families from the skin secretions of the Chachi treefrog, Boana picturata
par: Morán Marcillo, Giovanna
Publié: (2022)

Biochemical and functional studies of ColTx-I, a new myotoxic phospholipase A2 isolated from Crotalus oreganus lutosus (Great Basin rattlesnake) snake venom
par: de Almeida, José R.
Publié: (2016)

Peptidomic approach identifies cruzioseptins, a new family of potent antimicrobial peptides in the splendid leaf frog, Cruziohyla calcarifer.
par: Proaño Bolaños, Carolina
Publié: (2016)

Discovery of antimicrobial peptides in spider silk glands using Expressed Sequence Tag data
par: Sánchez Yumbo, Alex
Publié: (2021)

CoaTx-II, a new dimeric Lys49 phospholipase A2 from Crotalus oreganus abyssus snake venom with bactericidal potential: Insights into its structure and biological
par: de Almeida, José R.
Publié: (2016)

Bioactivity of synthetic peptides from Ecuadorian frog skin secretions against Leishmania mexicana, Plasmodium falciparum, and Trypanosoma cruzi
par: Proaño Bolaños, Carolina
Publié: (2024)

Assessing the stability of historical and desiccated snake venoms from a medically important Ecuadorian collection
par: de Almeida, José R.
Publié: (2020)

Novel antimicrobial cruzioseptin peptides extracted from the splendid leaf frog, Cruziohyla calcarifer
par: Cuesta, Sebastian A.
Publié: (2021)

Identification of key amino acid residues toward improving the catalytic activity and substrate specificity of plant-derived cytochrome P450 monooxygenases CYP716A subfamily enzyme for triterpenoid production in Saccharomyces cerevisiae
par: Romsuk, Jutapat
Publié: (2022)

Virtual screening of antiangiogenic cancer treatment peptides based on network science and a similarity searching based approach
par: Valarezo Albán, Andrea Karolina
Publié: (2024)

In silico discovery of hemolytic peptides through a novel approach based on network science and similarity searching methods
par: Castillo Mendieta, Kevin Alexis
Publié: (2023)

Bioactive peptides inspired on a LYS49 phospholipase a against bacteria and cancer cells
par: Valencia Orellana, Valeria Belén
Publié: (2023)

Theoretical screening of therapeutic peptides with potential anticancer activity
par: Romero Herdoiza, Maylin Fernanda
Publié: (2021)

Snake Venom, A Natural Library of New Potential Therapeutic Molecules: Challenges and Current Perspectives
par: Simoes Silva, Rodrigo
Publié: (2018)

A novel network science and similarity-searching-based approach for discovering potential antiviral peptides
par: De Llano García, Daniela
Publié: (2023)

“Revisión sistemática de incremento del reborde alveolar vertical mediante tres técnicas de injerto óseo”
par: Encalada Guamán, Erika Gabriela
Publié: (2023)

Construction and use of reporter genes to visualize protein and amino acid utilization in Candida albicans
par: Narváez Toapanta, Katherine Salomé
Publié: (2023)

“Coating porous membranes with a photocatalyst: Comparison of LbL self-assembly and plasma-enhanced CVD techniques”
par: Starr, B.J.
Publié: (2016)

Evaluation of branched-chain amino acid supplementation on productive performance and biochemical variables in weaned piglets
par: Paillacho Cabrera, Jorge Luis
Publié: (2022)

Production of the bioactive plant‐derived triterpenoid morolic acid in engineered Saccharomyces cerevisiae
par: Srisawat, Pisanee
Publié: (2020)

Proximate Analysis and Amino Acid Profile of the Ecuadorian Andean Lupin (Fabaceae: Lupinus mutabilis) Protein Isolate
par: Guerra Freire, Daniela
Publié: (2015)

Plant vs. Animal Protein: Comparative Biological Analysis of Digestibility, Amino Acid Profile, and Metabolic Effects
par: Bustillos, Diana
Publié: (2023)