Lessons from a Single Amino Acid Substitution: Anticancerand Antibacterial Properties of Two PhospholipaseA2-Derived Peptides

Lessons from a Single Amino Acid Substitution: Anticancerand Antibacterial Properties of Two PhospholipaseA2-Derived Peptides

The membrane-active nature of phospholipase A2-derived peptides makes them potentialcandidates for antineoplastic and antibacterial therapies. Two short 13-mer C-terminal fragmentstaken from snake venom Lys49-PLA2toxins (p-AppK and p-Acl), differing by a leucine/phenylalaninesubstitution, were synth...

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Bibliographic Details
Main Author: de Almeida, José R. (author)
Other Authors: Mendes, Bruno (author), Lancellotti, Marcelo (author), Franchi, Gilberto C. Jr. (author), Passos, Óscar (author), Ramos, Maria J. (author), Fernandes, Pedro A. (author), Alves, Cláudia (author), Vale, Nuno (author), Gomes, Paula (author), da Silva, Saulo L. (author)
Format: article
Published: 2021
Subjects:
Agkistrodon
Leucine;
Phenylalanine
Membrane;
Venom peptides
Online Access:https://doi.org/10.3390/cimb44010004A
http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/483
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