The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2

Hepatocyte nuclear factor 4 alpha (HNF4α) nuclear receptor is a master regulator of hepatocyte development, nutrient transport and metabolism. HNF4α is regulated both at the transcriptional and post-transcriptional levels by different mechanisms. Several kinases (PKA, PKC, AMPK) were shown to phosph...

• Main Author: Vető, Borbála (author)
• Other Authors: Bojcsuk, Dora (author), Bacquet Pérez, Caroline Nicole (author), Kiss, Judit (author), Sipeki, Szabolcs (author), Martin, Ludovic (author), Buday, Laszlo (author), Bálint, BL. (author), Arányi, Tamas (author)
• Format: article
• Published: 2017
• Subjects: Alpha (HNF4α); HNF4α; Nutrient; Metabolism
• Online Access: http://repositorio.ikiam.edu.ec/jspui/handle/RD_IKIAM/156; https://doi.org/10.1371/journal.pone.0172020