Comportamiento de la inmunosenescencia en pacientes portadores del virus de inmunodeficiencia humana (vih)

Inmunosenescencia is the decline of immune function with age. The immune system maintains the body's health. Age affects acquired immunity more than innate immunity Objective: to conduct an updated literature review on the behavior of immunosenescence in HIV-infected patients. Methods: A descriptive approach was utilized to investigate immunosenescence in HIV patients for the purpose of identifying clinical implications. A systematic literature review will be carried out following the PRISMA model with predefined inclusion criteria. Information will be retrieved from scientific databases using relevant MESH search terms. Results: accelerated immunosenescence in HIV patients leads to rapid deterioration of the immune system due to the chronic nature of the infection, increasing susceptibility to infections and immunological disorders. Changes in T lymphocytes affect the immune response, with a higher presence of memory cells and altered phenotypes. This can result in a decrease in the effectiveness of the immune response, increased autoantibodies, and a higher risk of autoimmune diseases. Personalized therapeutic strategies aim to improve these outcomes. Conclusion: HIV patients experience progressive immune deterioration with alterations in T lymphocytes and a higher presence of memory cells. This results in a compromised immune response, increased susceptibility to infections, and autoimmune disorders. Personalized therapeutic strategies are key to improving immune health in this vulnerable population.

• Main Author: Falconí Cobeña, Steffy Mishell (author)
• Format: bachelorThesis
• Language: spa
• Published: 2025
• Subjects: INMUNOSENESCENCIA; INMUNIDAD CELULAR; VIH; INMUNOCOMPETENCIA
• Online Access: https://dspace.uniandes.edu.ec/handle/123456789/18734