Multiple effects of the Na+/H+ antiporter inhibitor HMA on cancer cells

Amiloride derivatives are a class of new promising chemotherapeutic agents. A representative member of this family is the sodium-hydrogen antiporter inhibitor HMA (5-(N,N-hexamethylene amiloride), which has been demonstrated to induce cellular intracytosolic acidification and cell death through the...

• Autore principale: Guaman Ortiz, L. (author)
• Natura: article
• Pubblicazione: 2017
• Soggetti: myc amplification level; dnase; ii; apoptosis; amiloride; therapy; pathway; fibroblasts; resistance; phenotype; etoposide
• Accesso online: http://dx.doi.org/10.1007/s10495-013-0898-3; http://dspace.utpl.edu.ec/handle/123456789/19135