Pharmacological effects of PARP inhibitors on cancer and other diseases

Poly(ADP-ribosylation), a post-translational modification of proteins involved in DNA repair, replication, transcription and cell death, consists in the conversion of �-NAD + into ADP-ribose, and the further formation of polymers of variable length and structure bound to nuclear protein acceptors. P...

• Hovedforfatter: Guaman Ortiz, L. (author)
• Format: article
• Udgivet: 2011
• Fag: Cancer; Cell death; DNA repair; Inflammation; Neurodegenerative diseases; PARG inhibitors; PARP inhibitors; Poly(ADP-ribosylation); Tankyrases
• Online adgang: http://dspace.utpl.edu.ec/handle/123456789/19238