Phytometabolite Dehydroleucodine induces cell cycle arrest, apoptosis, and DNA damage in human astrocytoma cells through p73/p53 regulation

Accumulating evidence supports the idea that secondary metabolites obtained from medicinal plants (phytometabolites) may be important contributors in the development of new chemotherapeutic agents to reduce the occurrence or recurrence of cancer. Our study focused on Dehydroleucodine (DhL), a sesqui...

• 1. Verfasser: Malagon Aviles, O. (author)
• Weitere Verfasser: Bailon Moscoso, N. (author), Ostrosky-Wegman, P. (author), Ratovitski, . (author), Vidari, Giovanni Savino Pene, . (author), Zentella-Dehesa, A. (author), González, G. (author), Velásquez-Rojas, G. (author)
• Format: article
• Veröffentlicht: 2015
• Schlagworte: cyclin dependent kinase inhibitor 1A; dehydroleucodine; doxorubicin; gamma H2AX protein; Gynoxys verrucosa extract; histone H2AX; methanol; plant extract; protein Bax; protein p53; protein p73; sesquiterpene lactone; unclassified drug
• Online Zugang: http://dspace.utpl.edu.ec/handle/123456789/18971