Phytometabolite Dehydroleucodine induces cell cycle arrest, apoptosis, and DNA damage in human astrocytoma cells through p73/p53 regulation

Phytometabolite Dehydroleucodine induces cell cycle arrest, apoptosis, and DNA damage in human astrocytoma cells through p73/p53 regulation

Accumulating evidence supports the idea that secondary metabolites obtained from medicinal plants (phytometabolites) may be important contributors in the development of new chemotherapeutic agents to reduce the occurrence or recurrence of cancer. Our study focused on Dehydroleucodine (DhL), a sesqui...

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Autor principal: Malagon Aviles, O. (author)
Altres autors: Bailon Moscoso, N. (author), Ostrosky-Wegman, P. (author), Ratovitski, . (author), Vidari, Giovanni Savino Pene, . (author), Zentella-Dehesa, A. (author), González, G. (author), Velásquez-Rojas, G. (author)
Format: article
Publicat: 2015
Matèries:
cyclin dependent kinase inhibitor 1A
dehydroleucodine
doxorubicin
gamma H2AX protein
Gynoxys verrucosa extract
histone H2AX
methanol
plant extract
protein Bax
protein p53
protein p73
sesquiterpene lactone
unclassified drug
Accés en línia:http://dspace.utpl.edu.ec/handle/123456789/18971
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