Molecular docking for the study of the mechanism of action of miltefosine in the treatment of American Trypanosomiasis: a strategy for the rational design of drugs targeting parasite phospholipids and enzymes
In this study, the molecular interaction between miltefosine and ketoconazole with the enzyme phosphatidylethanolamine methyltransferase (PEMT) of Trypanosoma cruzi was evaluated through semiflexible molecular docking. PEMT was selected due to its role in the biosynthesis of ergosterol, a crucial co...
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| Format: | bachelorThesis |
| Language: | eng |
| Published: |
2025
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| Subjects: | |
| Online Access: | http://repositorio.yachaytech.edu.ec/handle/123456789/940 |
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